Abstract
The capillary supply of the heart is traditionally characterized by the mean capillary density, i.e. the number of capillaries per unit area of tissue cross-section. It is possible to estimate the average inter-capillary distance using the data on capillary density and accepting a certain uniform geometrical arrangement of the capillary network. The average intercapillary distance then yields the radius of the tissue cylinder supplied by a single capillary which can be used in calculation of myocardial PO2 according to the Krogh-Erlang equation (1). A basic deficiency inherent in such a calculation is that a uniform distribution of capillaries is assumed. However, it has been shown both by measurements in vitro (histology, e.g. (2)) and in vivo (cinemicrophotography, e.g. (3)) that this is not the case. The heterogeneity of capillary spacing, in turn, has a pronounced effect on myocardial oxygenation as demonstrated in a series of our theoretical studies (4, 5). Until recently, there was no method available to evaluate the pattern of distribution of capillaries in histological sections. Recently, several methods for direct or indirect estimates of the heterogeneity of capillary spacing have been proposed (method of concentric circles (6); triangular method (7); closest individual method (8); capillary domains (9)).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Krogh, A. J. Physiol. (London) 52: 409–415, 1919.
Rakusan, K., Moravec, J. and Hatt, P.Y. Microvasc. Res. 20: 319–326, 1980.
Bourdeau-Martini, J. and Honig, C. Microvasc. Res. 6: 286–296, 1973.
Turek, Z. and Rakusan, K. Pflügers Arch. 391: 17–21, 1981.
Rakusan, K., Hoofd, L.J.C. and Turek, Z. In: Oxygen Transport to Tissue VI (Eds. D. Bruley, H.I. Bicher and D. Reneau), Plenum Press, New York and London, 1984, pp. 463–476.
Loats, J.T., Sillay, A.H. and Banchero, N. In: Oxygen Transport to Tissue III (Eds. I.A. Silver, M. Erecinska, H.I. Bicher), Plenum Press, New York and London, 1978, pp. 41–52.
Renkin, E.M., Gray, S.D., Dodd, L.R. and Lia, B.D. In: Underwater Physiology VII (Eds. A.J. Bachrach and M.M. Matzen), Undersea Medical Soc, Bethesda, 1981, pp. 465–474.
Kayar, S.R., Archer, P.G., Lechner, A.J. and Banchero, N. Microvasc. Res. 24: 326–341, 1982.
Hoofd, L., Turek, Z., Kubat, K., Ringnalda, B.E.M. and Kazda, S. In: Oxygen Transport to Tissue VII (Eds. F. Kreuzer, S.M. Cain, Z. Turek and T.K. Goldstick), Plenum Press, New York and London, 1985, pp. 239–247
Rakusan, K. and Turek, Z. Circulation Res. 57: 393–398, 1985.
Turek, Z., Hoofd, L. and Rakusan, K. Can. J. Cardiol. 2: 98–103, 1986.
Rakusan, K. and Korecky, B. Can. J. Cardiol. 1: 217–222, 1985.
Rakusan, K. Methods Achiev. Exp. Pathol. 5: 272–286, 1971.
Shipley, R.A., Shipley, L.J. and Wearn, J.T. J. Exp. Med. 65: 29–41, 1937.
Roberts, V.T. and Wearn, J.T. Am. Heart J. 21: 617–632, 1941.
Honig, C.R., Gayeski, T.E.J., Federspiel, W., Clark, A. and Clark P. In: Oxygen Transport to Tissue V (Eds. D.W. Lübbers, H. Acker, E. Leniger-Follert and T.K. Godlstick), Plenum Press, New York and London, 1984, pp. 23–38.
Honig, C.R. and Gayeski, T.E.J. Proc. Int. Union Physiol. Sci. XVI, p. 338.
Hoofd, L., Turek, Z., and Rakusan, K. In: Oxygen Transport to Tissue IX, Plenum Press, New York and London, in press.
Jones, D.P. Am. J. Physiol. 250: C663–C675, 1986.
Mainwood, G.W. and Rakusan, K. Can. J. Physiol. Pharmacol. 60: 99–102, 1982.
Rakusan, K. and Tomanek, R.J. J. Mol. Cell Cardiol. 18: 299–305, 1986.
Kayar, S.R., Conley, K.E., Claassen, H. and Hoppeler, H. J. Exp. Biol. 120: 189–199, 1986.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Rakusan, K., Turek, Z. (1987). Oxygen Sources and Sinks in Myocardial Hypertrophy. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_5
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2051-7_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9219-7
Online ISBN: 978-1-4613-2051-7
eBook Packages: Springer Book Archive