Skip to main content
SpringerLink
Log in

The Hypothyroid State in Cardiomyopathic Hamsters

  • Chapter
Pathophysiology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 65))

Abstract

Degeneration of the heart muscle in cardiomyopathic (CM) hamsters follows a staging pattern which thus far has received little explanation. The ventricular myosin changes with time course of the disease (1) and the impaired responsiveness to catecholamines (2) in these animals are two untoward features that led us to investigate the thyroid function. It is commonly accepted that the pathologic changes in myopathic hearts become evident after 30 days of age (3–7). This stands for a depressed oxidative metabolism or changes in activity of ATPases which concur to the necrotizing process (8, 9). Similar metabolic inadequacies have been equally observed in hypothyroid or diabetic hearts (10, 11) and it seemed all important to appraise the vulnerability of heart muscle cells in hamsters as it may relate to thyroid function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jasmin, G., Proschek, L. and Dechesne, C. J. Mol. Cell. Cardiol. 18:233, 1986.

    Google Scholar 

  2. Jasmin, G. and Proschek, L. Muscle & Nerve 6:408–415, 1983.

    Article  CAS  Google Scholar 

  3. Bajusz, E. Amer. Heart J. 77:686–696, 1969.

    Article  PubMed  CAS  Google Scholar 

  4. Gertz, E.W. In: Progress in Experimental Tumor Research. Vol. 16. Ed. F. Homburger. S. Karger, Basel, 1972, pp. 242–260.

    Google Scholar 

  5. Jasmin, G. and Bajusz, E. In: Recent Advances in Studies on Cardiac Structure and Metabolism. Vol. 6. Eds. A. Fleckenstein and G. Rona. University Park Press, Baltimore, 1975, pp. 219–229.

    Google Scholar 

  6. Strobeck, J.E., Factor, S.M., Bhan, A., Sole, M., Liew, C.C., Fein, F. and Sonnenblick, E.H. Ann. N.Y. Acad. Sci. 317:59–88, 1979.

    PubMed  CAS  Google Scholar 

  7. Jasmin, G. and Proschek, L. Muscle & Nerve 5:20–25, 1982.

    Article  CAS  Google Scholar 

  8. Dhalla, N.S., Singh, A., Lee, S.L., Anand, M.B., Bernatsky, A.M. and Jasmin, G. Clinical Science & Mol. Med. 49:359–368, 1975.

    CAS  Google Scholar 

  9. Proschek, L. and Jasmin, G. Muscle & Nerve 5:26–32, 1982.

    Article  CAS  Google Scholar 

  10. Suko, J. Biochim. Biophys. Acta 252:324–327, 1971.

    PubMed  CAS  Google Scholar 

  11. Tahiliani, A.G. and McNeill, J.H. Can. J. Physiol. Pharmacol. 62:617–621, 1984.

    Article  PubMed  CAS  Google Scholar 

  12. Bouvagnet, P., Léger, J., Pons, F., Dechesne, C. and Léger, J.J. Circ. Res. 55;784–804, 1982.

    Google Scholar 

  13. Malhotra, A., Karrell, M. and Scheuer, J. J. Mol. Cell. Cardiol. 17:95–107, 1985.

    Article  CAS  Google Scholar 

  14. Wiegand, V., Strohl, E., Henniges, A., Lossnitzer, K. and Kreuzer, H. Basic Res. Cardiol. 78:665–670, 1983.

    Article  PubMed  CAS  Google Scholar 

  15. Jasmin, G., Proschek, L. and Dechesne, C. J. Mol. Cell. Cardiol. 18:127, 1986.

    Google Scholar 

  16. Watson, A.Y., Radie, K., McCarthy, M., Larsen, P.R. and Murphy, R.A. Endocrinology 110:1392–1401, 1982.

    Article  PubMed  CAS  Google Scholar 

  17. King, D.B., King, C.R. and Jacaruso, R.B. Life Sciences 28:577–585, 1981.

    Article  PubMed  CAS  Google Scholar 

  18. Makino, N., Jasmin, G., Beamish, R.E. and Dhalla, N.S. Biochem. Biophys. Res. Comm. 133:491–497, 1985.

    Article  PubMed  CAS  Google Scholar 

  19. Schwartz, A., Lendenmayer, G.E., Allen, J.C. Curr. Top. Memb. Transp. 3:l-82, 1972.

    Google Scholar 

  20. Dhalla, N.S., Pierce, G.N., Panagia, V., Singal, P.K. and Beamish, R.E. Basic Res. Cardiol. 77:117–139, 1982.

    Article  PubMed  CAS  Google Scholar 

  21. Wagner, J.A., Reynolds, I.J., Weisman, H.F., Dudeck, P., Weisfeldt, M.L. and Snyder, S.H. Science 232:515–518, 1986.

    Article  PubMed  CAS  Google Scholar 

  22. Jasmin, G. and Proschek, L. Can. J. Physiol. Pharmacol. 62:891–898, 1984.

    Article  PubMed  CAS  Google Scholar 

  23. Jasmin, G. and Proschek, L. In: Calcium Antagonists. Mechanisms of Action on Cardiac Muscle and Vascular Smooth Muscle. Eds. N. Sperelakis and J.B. Caulfield. Martinus Nijhoff Publishing, Boston, 1984, pp. 229–239.

    Google Scholar 

  24. Sievers, R., Wikman-Coffelt, J., Parmley, W.W. and Jasmin, G. Amer. J. Physiol. 250:H22–H28, 1986.

    PubMed  Google Scholar 

  25. Angelakos, E.T., King, M.P. and Carballo, L. In: Recent Advances in Studies on Cardiac Structure and Metabolism. Eds. E. Bajusz and G. Rona. University Park Press, Baltimore, 1973, pp. 519–531.

    Google Scholar 

  26. Lossnitzer, K., Janke, J., Hein, B., Stauch, M. and Fleckenstein, A. In: Recent Advances in Studies on Cardiac Structure and Metabolism. Eds. A. Fleckenstein and G. Rona. University Park Press, Baltimore, 1975, pp. 207–217.

    Google Scholar 

  27. Sole, M.J., Lo, C.M., Laird, C.W., Sonnenblick, E.H. and Wurtman, R.J. Circ. Res. 37:855–862, 1975.

    PubMed  CAS  Google Scholar 

  28. Rossner, K.L. Cardiovascular Res. 19:584–588, 1985.

    Article  CAS  Google Scholar 

  29. Kunos, G. Br. J. Pharmacol. 59:1777, 1977.

    Google Scholar 

  30. Lefkowitz, R.J., Caron, M.G. and Stiles, G.L. New England J. Med. 310:1570–1579, 1984.

    Article  CAS  Google Scholar 

  31. Berresdal, M. Biochem. J. 220:345–360, 1984.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pathology and Biochemistry, Université de Montréal, Winnipeg, USA

    G. Jasmin, L. Proschek, G. Brisson & N. S. Dhalla

  2. Department of Physiology, University of Manitoba, Winnipeg, USA

    G. Jasmin, L. Proschek, G. Brisson & N. S. Dhalla

Authors
  1. G. Jasmin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Proschek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Brisson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. S. Dhalla
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, Youville Research Institute, St. Boniface General Hospital and University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Pawan K. Singal  & Robert E. Beamish ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Jasmin, G., Proschek, L., Brisson, G., Dhalla, N.S. (1987). The Hypothyroid State in Cardiomyopathic Hamsters. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2051-7_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9219-7

  • Online ISBN: 978-1-4613-2051-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation