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Pathophysiology of Anthracycline-Induced Cardiomyopathy

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Pathophysiology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 65))

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Abstract

The pathophysiological events leading to anthracycline cardiomyopathy remain unclear in spite of intensive investigations. Major factors are thought to include stimulation of chemical processes giving rise to superoxide or hydroxyl radicals capable of causing oxidative damage to cellular membranes and thereby changes in subcellular organelles (1,2). It has also been suggested that anthracycline toxicity may arise from increased myocardial permeability resulting from induced deficiency of protective mechanisms. This could be reflected by an alterations in such enxymes as catalase, superoxide dismutase and glutathione peroxidase (3,4,5).

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Author information

Authors and Affiliations

  1. Departments of Medicine (Division of Cardiology), and Pharmacology, University of British Columbia, Vancouver, BC, Canada

    C. W. Tomlinson, J. H. McNeill & D. V. Godin

  2. Therapeutics, Faculty of Medicine and Division of Pharmacology, University of British Columbia, Vancouver, BC, Canada

    C. W. Tomlinson, J. H. McNeill & D. V. Godin

  3. Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

    C. W. Tomlinson, J. H. McNeill & D. V. Godin

Authors
  1. C. W. Tomlinson
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  2. J. H. McNeill
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  3. D. V. Godin
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Editor information

Editors and Affiliations

  1. Department of Physiology, Youville Research Institute, St. Boniface General Hospital and University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Pawan K. Singal  & Robert E. Beamish ,  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Tomlinson, C.W., McNeill, J.H., Godin, D.V. (1987). Pathophysiology of Anthracycline-Induced Cardiomyopathy. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_21

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  • DOI: https://doi.org/10.1007/978-1-4613-2051-7_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9219-7

  • Online ISBN: 978-1-4613-2051-7

  • eBook Packages: Springer Book Archive

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