Abstract
Many studies have demonstrated changes in plasma and cardiac norepinephrine (NE) levels in diabetes (1–4). In addition, experimentally-induced diabetes has been shown to be associated with bradycardia, decrease in numbers of β-adrenergic receptors and reduction in the inotropic effects of NE in hearts (5–7). Since excessive amounts of catecholamines are known to cause myocardial cell damage (8), it is possible that high levels of plasma catecholamines in diabetes may be accompanied by structural changes in the cardiac muscle (1). Accordingly, the present study was undertaken to examine the relationship of changes in plasma catecholamines with the occurrence of ultrastructural abnormalities during the development of streptozotocin-induced diabetic cardiomyopathy, Experiments were also carried out to investigate whether the observed changes in diabetes are reversible upon treatment with insulin.
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References
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© 1987 Martinus Nijhoff Publishing, Boston
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Ganguly, P.K., Dhalla, K.S., Beamish, R.E., Innes, I.R., Dhalla, N.S. (1987). Involvement of Catecholamines in the Development of Diabetic Cardiomyopathy. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_18
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DOI: https://doi.org/10.1007/978-1-4613-2051-7_18
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