Abstract
Free fatty acids (FFA) are the preferred substrate for the heart. The sources of FFA for myocardial oxidation are shown in Fig. 1 and include:
-
(a)
circulating albumin-bound FFA, derived from the degradation of triacylglycerols (TG) in adipose tissue depots;
-
(b)
hydrolysis of the TG component of circulating lipoproteins (for example, very-low density lipoprotein or VLDL-TG) by an enzyme, lipoprotein lipase (LPL), that is located at the capillary endothelium, and that can be released by heparin;
-
(c)
hydrolysis of endogenous TG by an intracellular TG lipase (myo-cardial lipolysis).
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Severson, D.L., Kenno, K.A., Larsen, T.S., RamÃrez, I. (1987). Triacylglycerol Lipase Activities and Rates of Endogenous Lipolysis in Myocardial Cells from Diabetic Rat Hearts. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_17
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