Role of the Basic Sciences in the Practice of Cardiology

  • Arnold M. Katz
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 65)


The hallmark of the cardiologist is the skill with which he recognizes and treats all aspects of heart failure. However, no physician should undertake the treatment of heart failure without a thorough understanding of what is and what is not heart failure; the importance, in achieving an optimal therapeutic success, of identifying both the nature of the underlying heart disease and the factors immediately responsible for precipitating heart failure; the drugs and other measures effective in the management of heart failure and their integration into a sound rationale of therapy; and the harm that may be caused by therapy injudiciously or erroneously applied.


Acute Myocardial Infarction Sarcoplasmic Reticulum Cardiogenic Shock Myocardial Contractility Cardiac Glycoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Silber, E.N. and Katz, L.N. Heart Disease. MacMillan Publishing Co. Inc. New York, 1975.Google Scholar
  2. 2.
    Hearse, D.J., Braimbridge, M.V., Jynge, P. Protection of the Ischemic Myocardium: Cardioplegia. Raven Press, NY, 1981.Google Scholar
  3. 3.
    Hearse, D.J., Yellon, D.M. Therapeutic Approaches to Myocardial Infarct Size Limitation. Raven Press, NY, 1984.Google Scholar
  4. 4.
    Meerson, F.Z. Cor et Vasa 3:161–177, 1961.PubMedGoogle Scholar
  5. 5.
    Meerson, F.Z. The Failing Heart: Adaptation and Deadaptation. Raven Press, NY, 1983.Google Scholar
  6. 6.
    Cohn, J.N., Archibald, D.G., Ziesche, S., Franciosa, J.A., Harston, W.E., Tristani, F.E., Dunkman, W.B., Jacobs, W., Francis, G.S., Flohr, K.H., Goldman, S., Cobb, F.R., Shah, P.M., Saunders, R., Fletche, R.D., Loeb, H.S., Hughes, V.C., Baker, B. New Eng J Med 314: 1547–1552, 1986.PubMedCrossRefGoogle Scholar
  7. 7.
    Katz, A.M., Reuter, H. Am. J. Cardiol. 44:188–190, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Rinke, CM. JAMA 255:2991–2992, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    White, P.D. Heart Disease 4th Edition. MacMillan Publishing Co. Inc. New York, 1951.Google Scholar
  10. 10.
    Levine, S.A. Clinical Heart Disease 4th Edition. WB Saunders Co, Philadelphia, 1951.Google Scholar
  11. 11.
    Hellerstein, H.K., Brofman, B.L., Caskey, W.H. Am Heart J 44:407–427, 1952.PubMedCrossRefGoogle Scholar
  12. 12.
    Gazes, P.C., Goldberg, L.I., Darby, T.D. Circulation 8:883–892, 1953.PubMedGoogle Scholar
  13. 13.
    Hurst, J.W. and Logue, R.B. The Heart Arteries and Veins. McGraw Hill Book Company. New York, 1966.Google Scholar
  14. 14.
    Friedberg, C.F. Diseases of the Heart 3rd Edition. W.B. Saunders Co., Philadelphia, 1966.Google Scholar
  15. 15.
    Evans, C.L. and Matsuoka, Y. J Physiol (London) 49:378–405, 1915.Google Scholar
  16. 16.
    Katz, L.N., Katz, A.M., Williams, F.L. Am J Physiol 181:539–549. 1955.PubMedGoogle Scholar
  17. 17.
    Bing, R.J. The metabolism of the heart. Harvey Lect. L:27–70 1954.Google Scholar
  18. 18.
    Dawes, G.S., Comroe, J.H.Jr. Physiol. Rev. 34:167–201, 1954.Google Scholar
  19. 19.
    Katz, A.M. J Am Coll Cardiol 1:42–51, 1983.PubMedCrossRefGoogle Scholar
  20. 20.
    Hurst, J.W. The Heart, Arteries and Veins, 3rd Edition. McGraw Hill Book Company. New York, 1974.Google Scholar
  21. 21.
    Hurst, J.W. The Heart, Arteries and Veins 4th Edition. McGraw Hill Book Company. New York, 1978.Google Scholar
  22. 22.
    Goldman, L., Cook, E.F. Ann. Int. Medicine 101:825–836, 1984.Google Scholar
  23. 23.
    Braunwald, E. Heart Disease, A Textbook of Cardiovascular Medicine 1st Edition. W.B. Sanders Company. Philadelphia, 1980.Google Scholar
  24. 24.
    Braunwald, E. Heart Disease, A Textbook of Cardiovascular Medicine 2nd Edition. W.B. Sanders Company. Philadelphia, 1984.Google Scholar
  25. 24A.
    Hurst, J.W. The Heart, Arteries and Veins, 5th Edition. McGraw Hill Book Company. New York. 1982.Google Scholar
  26. 25.
    Mulrow, CD., Feussner, J.R. Velez, R. Ann Int Med 101:113–117. 1984.Google Scholar
  27. 26.
    Ross, J., Jr. Prog Cardiovasc Dis 18:255–264, 1976.CrossRefGoogle Scholar
  28. 27.
    Scholz, H. J Am Coll Cardiol 4:289–397, 1984.CrossRefGoogle Scholar
  29. 28.
    Lee, CO., Abete, P., Pecker, M, Sonn, J.K, Vasalle, M. J Mol Cell Cardol 17:1043–1053, 1985.CrossRefGoogle Scholar
  30. 29.
    Katz, A.M. Circulation 47:1076–1079, 1973.PubMedGoogle Scholar
  31. 30.
    Katz, A.M. N Eng J Med 299:1409–1410, 1978.CrossRefGoogle Scholar
  32. 31.
    LeJemtel, T.H., Sonnenblick, E.H. N Eng J Med 310:1384–1385, 1984.CrossRefGoogle Scholar
  33. 32.
    Anderson, J.L., Lutz, J.R., Gilbert, E.M., Sorensen, S.G., Yanowitz, F.G., Menlove, R.L., Bartholomew, M. Am J Cardiol 55:471–475, 1985.PubMedCrossRefGoogle Scholar
  34. 33.
    Engelmeier, R.S., O’Connell, J.B., Walsh, R., Rad, N., Scanlon, P.J., Gunnar, R.M. Circulation 72:536–546, 1985.PubMedCrossRefGoogle Scholar
  35. 34.
    Alderman, J., Grossman, W., Circ 71:854–857, 1985.CrossRefGoogle Scholar
  36. 35.
    Solaro, J.R., Ruegg, J.C. Circ Res 51:290–294.Google Scholar
  37. 36.
    Lullman, H., Peters, J., Ravens, U. Pharmacol. Ther. 21:229–245, 1983.CrossRefGoogle Scholar
  38. 37.
    Katz, A.M. Physiol. Rev. 50:63–158, 1970.PubMedGoogle Scholar
  39. 38.
    Swynghedauw, B. Physiol Rev In Press. 1986.Google Scholar
  40. 39.
    Katz, A.M. Circulation 73:(Suppl. III) III-184 – III-188, 1986.Google Scholar
  41. 40.
    Unverferth, D.V., Magorien, R.D, Kolibash, A.J., Lewis, R.P., Lykens, M., Altschuld, R., Baba, N., Leier, C.V. Int J Cardiol 1:133–142, 1981.PubMedCrossRefGoogle Scholar
  42. 41.
    Brutsaert, D.L., Meijler, F.L. Eur Heart J 1(Suppl A):1, 1980.Google Scholar
  43. 42.
    Grossman, W., Barry, W.H. Federation Proc 39:148–155, 1980.Google Scholar
  44. 43.
    Bonow, R.O., Bacharach, S.L., Green, M.V., Kent, K.M., Rosing, D.R., Lipson, L.C., Leon, M.B., Epstein, S.E. Circulation 64:315–323, 1981.PubMedCrossRefGoogle Scholar
  45. 44.
    Smith, V-E., Schulman, P., Karimeddini, M.K., White, W.B., Meeran, M.K., Katz, A.M. J Am Coll Cardiol 5:869–874, 1985.PubMedCrossRefGoogle Scholar
  46. 45.
    Tsien, R.W. Ann Rev Physiol 45:341–358, 1983.CrossRefGoogle Scholar
  47. 46.
    Shigekawa, M., Finegan, J-AM., Katz, A.M. J Biol Chem 251:6894–6900, 1976.PubMedGoogle Scholar
  48. 47.
    Katz, A.M., Takenaka, H., Watras, J. The sarcoplasmic reticulum. In: The Heart and Cardiovascular System. Ed: Fozzard HM, Haber E, Jennings RB, Katz AM, Morgan HE. Raven Press, NY. In Press, 1986.Google Scholar
  49. 48.
    Shigakawa, M., Dougherty, J.P., Katz, A.M. J Biol Chem 253:1442–1450, 1978.Google Scholar
  50. 49.
    Nakamura, Y., Tonomura, Y. J Bioeng Biomed 14:307–318, 1982.Google Scholar
  51. 50.
    Katz, A.M., Tada, M. Am J Cardiol 29:578–580, 1972.PubMedCrossRefGoogle Scholar
  52. 51.
    Smith, V-E., Katz, A.M. Eur Heart J 4(Suppl A):7–17, 1983.PubMedGoogle Scholar
  53. 52.
    Kass, R.S., Lederer, W.J., Tsien, R.W., Weingart, R. J Physiol (Lond) 281:187–208, 1978.Google Scholar
  54. 53.
    Colquhoun, D., Neher, E., Reuter, H., Stevens, C.F. Nature 294:752–294, 1981.PubMedCrossRefGoogle Scholar
  55. 54.
    Morgan, J.P., Chesebro, J.H., Pluth, J.R., Puga, F.J., Schaff, H.V. J Am Coll Cardiol 3:410–418, 1983.CrossRefGoogle Scholar
  56. 55.
    Rosen, M.R., Reder, R.R. Ann Int Med 94:794–801, 1982.Google Scholar
  57. 56.
    Lubbe, W.F., Pozuweit, Th., Daries, P.S., Opie, L.H. J Clin Invest 61:1260–1269. 1978.PubMedCrossRefGoogle Scholar
  58. 57.
    Katz, A.M. Adv Cyclic Nucl Res 11:303–343, 1979.Google Scholar
  59. 58.
    Katz, A.M. J Am Coll Cardiol 2:143–149, 1983b.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Arnold M. Katz
    • 1
  1. 1.Cardiology Division, Department of MedicineUniversity of ConnecticutFarmingtonUSA

Personalised recommendations