Abstract
The mammary gland is composed of epithelial, adipose, and connective tissues, and during mammary development the epithelium proliferates within the mammary fat pad (adipose and connective tissues) so that the relative proportion of each tissue type varies depending on the developmental state of the gland. The gland in the nulliparous female mouse is composed mainly of adipose and connective tissue, whereas during pregnancy and lactation, the glandular epithelium predominates [1,2]. In a series of elegant experiments, De Ome and his colleagues have demonstrated that the normal mammary epithelium can grow only in the mammary fat pad [3–6]. Almost all aspects of the development and differentiation of normal mammary glands are under multihormonal control involving both steroid and protein hormones [7]. Thus, ultimately, the development of normal mammary epithelium involves a complex interplay between the various hormones regulating mammary growth and the various cell types present in the tissue.
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© 1987 Martinus Nijhoff Publishing, Boston
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Shyamala, G. (1987). Endocrine and other Influences in the Normal Development of the Breast. In: Paterson, A.H.G., Lees, A.W. (eds) Fundamental Problems in Breast Cancer. Developments in Oncology, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2049-4_15
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DOI: https://doi.org/10.1007/978-1-4613-2049-4_15
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