Abstract
Of all the potential complications of malignant melanoma, none is more devastating or life threatening than the development of central nervous system (CNS) metastases. Once this occurs most patients are dead within a few months. While treatment may improve symptoms, it does little to prolong life in the majority of patients. Indeed, no effective methods of prevention or treatment have been devised to date, and these are urgently needed if we are to look forward to long-term survival and cure of such patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker GS Kernohan JW, Kiefer EJ: Metastatic tumors of the brain. Surg Clin N Am 31:1143–1145, 1972.
Chason JL, Walker FB, Landers JW: Metastatic carcinoma in the central nervous system and dorsal root ganglia: A prospective autopsy study. Cancer 16:781–787, 1963.
Amer MH, AlSarraf M, Baker LH, Vaitkevicius VK: Malignant melanoma and central nervous system metastases Cancer 42:660–668, 1978.
Madajewicz S, Karakousis C West CR, Caracandas J, Avellanosa AM: Malignant melanoma brain metastases: Review of Roswell Park Memorial Institute experience. Cancer 53:2550–2552, 1984.
Stevens RN, Robinson WA: Brain metastases in malignant melanoma. Clinical Res 34:76A, 1986.
Crombie IK: Distribution of malignant melanoma on the body surface. Br J Cancer 43:842–849, 1981.
Jobe KA, Stears JC, Robinson WA: Patterns of distribution of CNS metastases in malignant melanoma. Clinical Res 34:75A, 1986.
Batson OV: The vertebral vein system as a mechanism for the spread of metastases. Am J Roentgenology 715–718, 1942.
Kindt GW: The pattern of location of cerebral metastatic tumors. J Neurosurg 21:54–57, 1964.
Carella RJ, Gelber R, Hendrickson F, Berry HC, Cooper JS: Value of radiation therapy in the management of patients with cerebral metastases from malignant melanoma: Radiation therapy oncology brain metastases study I and II. Cancer 45:679–683, 1980.
Habermaiz A, Fischer J: Radiation therapy of malignant melanoma experience with individual treatment doses. Cancer 38:2258–2262, 1976.
Withers HR, Harter D: Radiotherapy in the management of malignant melanoma. In: Neoplasms of the skin and malignant melanoma. Chicago: Yearbook Medical Publishers, 1976.
Stridsklev IC, Hagen S, Klepp O: Radiation therapy for brain metastases from malignant melanoma. ACTA Radiol Onc 23:231–235, 1984.
Thomas MR, Robinson WA, Glode LM, Dantas ME, Koeppler H, Morton N, Sutherland J: Treatment of advanced malignant melanoma with high dose chemotherapy and autologous bone marrow transplantation. Preliminary results-Phase I study. Am J of Clin Oncol 5:611–622, 1982.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Robinson, W.A., Jobe, K., Stevens, R. (1987). Central nervous system metastases in malignant melanoma. In: Nathanson, L. (eds) Basic and Clinical Aspects of Malignant Melanoma. Cancer Treatment and Research, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2043-2_8
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2043-2_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9215-9
Online ISBN: 978-1-4613-2043-2
eBook Packages: Springer Book Archive