The Pathology of IgA Nephropathy

  • Raja Sinniah
Part of the Topics in Renal Medicine book series (TIRM, volume 2)


Mesangial IgA nephropathy was first identified in France by Berger in 1968 [1, 2], and has been referred to as Berger’s disease. The lesion is characterized by diffuse mesangial deposition of immunoglobulins, with IgA predominating. There should be no systemic manifestations, and secondary diseases of systemic lupus erythematosus [3], Henoch-Schönlein purpura [4, 5], liver cirrhosis [6–8], and cancer, especially mucin-secreting adenocarcinomas [9, 10] should be excluded, as they are also known to have IgA deposits in the glomerular mesangium. The glomerular immunopathology of IgA nephropathy is identical with that of Henoch-Schönlein purpura, and some authors believe that IgA nephropathy is a forme fruste of Henoch-Schönlein purpura.


Mesangial Cell Glomerular Basement Membrane Mesangial Matrix Glomerular Lesion Capillary Loop 
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© Martinus Nijhoff Publishing, Boston 1987

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  • Raja Sinniah

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