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Summary of the Pathogenesis of IgA Nephropathy

  • Andrew J. Woodroffe
Chapter
Part of the Topics in Renal Medicine book series (TIRM, volume 2)

Abstract

As in so many conditions, the causes of IgA nephropathy and its close relative, Henoch-Schönlein purpura (HSP), remain obscure despite considerable efforts in human and animal experimentation. However, such efforts over the past ten years have taught us something about the mechanisms involved in mesangial IgA nephritis and this chapter reviews this knowledge, paying special tribute to those involved and emphasizing areas that may prove ultimately to be of diagnostic, prognostic, or therapeutic value to patients with IgA nephropathy.

Keywords

Systemic Lupus Erythematosus Mesangial Deposit Control Peripheral Blood Mononuclear Cell Tonsillar Cell Raji Cell Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Woodroffe AJ, Clarkson AR, Seymour AE, Lomax-Smith JD: Mesangial IgA nephritis. Springer Semin Immunopathol 5:321–332, 1982.PubMedCrossRefGoogle Scholar
  2. 2.
    Miyazaki R, Kuroda M, Akiyama T, Otani I, Tofuku Y, Takeda R: Glomerular deposition and serum levels of complement control proteins in patients with IgA nephropathy. Clin Nephrol 21:335–340, 1984.PubMedGoogle Scholar
  3. 3.
    Andre C, Berthoux FC, Andre F, Gillon J, Genin C, Sabatier J-C: Prevalence of IgA2 deposits in IgA nephropathies. N Engl J Med 303:1343–1346, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Conley ME, Cooper MD, Michael AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432–1436, 1980.PubMedCrossRefGoogle Scholar
  5. 5.
    Tomino Y, Endoh M, Nomoto Y, Sakai H: Immunoglobulin A1 in IgA nephropathy. N Engl J Med 305:1159–1160, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour AE, Woodroffe AJ: The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113:359–364, 1983.PubMedGoogle Scholar
  7. 7.
    Katz A, Nenkirk MM, Klein MH: Circulating and mesangial IgA in IgA nephropathy. Contrib Nephrol 40:74–79, 1984.PubMedGoogle Scholar
  8. 8.
    Tomino Y, Sakai H, Miura M, Endoh M, Nomoto Y: Detection of polymeric I in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419–425, 1982.PubMedGoogle Scholar
  9. 9.
    Egido J, Sancho J, Blasco R, Lozano L, Hernando L: Immunologic aspects of IgA nephropathy in humans. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 652–664.Google Scholar
  10. 10.
    Monteiro RC, Habwachs-Mecarelli L, Berger J, Lesavre P: Characteristics of eluted IgA in priamry IgA nephropathy. Contrib Nephrol 40:107–111, 1984.PubMedGoogle Scholar
  11. 11.
    Egido J, Sancho J, Mampaso F, Lopez-Trascasa M, Sanchez-Crespo M, Blasco R, Hernando L: A possible common pathogenesis of the the mesangial IgA glomerulonephritis in patients with Berger’s disease and Schönlein-Henoch syndrome. Proc Eur Dial Transplant Assoc 17:660–666, 1980.PubMedGoogle Scholar
  12. 12.
    Valentijn RM, Radi J, Haayman JJ, Vermeer BJ, Weening JJ, Kauffmann RH, Daha MR, van Es LA: Macromolecular IgA in the circulation and mesangial deposits in patients with primary IgA nephropathy. Contrib Nephrol 40:87–92, 1984.PubMedGoogle Scholar
  13. 13.
    Droz D, Noel LH, Barbanel C, Leibowitch J: Glomérulonéphrite à dépôts intercapillaires d’I lors d’une gammapathie monoclonale benigne. Nouv Presse Med 10:3652–3653, 1981.PubMedGoogle Scholar
  14. 14.
    Lowance DC, Mullins JD, Mhaul JJ: Immunoglobulin A (IgA) associated glomerulonephritis. Kideny Int 3:167–176, 1973.CrossRefGoogle Scholar
  15. 15.
    Tomino Y, Endoh M, Nomoto Y, Sakai H: Specificity of eluted antibody from renal tissue of patients with IgA nephropathy. Am J Kidney Dis 1:276–280, 1982.PubMedGoogle Scholar
  16. 16.
    Tomino Y, Sakai H, Endoh M, Suga T, Miura M, Kaneshige H, Nomoto Y: Cross-reactivity of IgA antibodies between renal mesangial areas and nuclei of tonsillar cells in patients with IgA nephropathy. Clin Exp Immunol 51:605–610, 1983.PubMedGoogle Scholar
  17. 17.
    Emancipator SN, Gallo GR, Lamm ME: Experimental IgA nephropathy induced by oral immunization. J Exp Med 157:572–582, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Sinniah R, Ku G: Clinicopathologic correlations in IgA nephropathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 665–685.Google Scholar
  19. 19.
    Pfaffenbach G, Lamm ME, Gigli I: Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes. J Exp Med 155:231–247, 1982.PubMedCrossRefGoogle Scholar
  20. 20.
    Scharschmidt LA, Dunn MJ: Prostaglandin synthesis by rat glomerular mesangial cells in culture: effect of angiotensin II and arginine vasopressin. J Clin Invest 71:1756–1764, 1983.PubMedCrossRefGoogle Scholar
  21. 21.
    Hooke DH, Hancock WW, Gee DC, Kraft N, Atkins RC: Monoclonal antibody analysis of glomerular hypercellularity in human glomerulonephritis. Clin Nephrol 22:163–168, 1984.PubMedGoogle Scholar
  22. 22.
    Schreiner GF, Cotran RS: Localization of an la-bearing glomerular cell in the mesangium. J Cell Biol 94:483–488, 1982.PubMedCrossRefGoogle Scholar
  23. 23.
    Couser WG: Mesangial IgA nephropathies: steady progress. West Med 140:89–91, 1984.Google Scholar
  24. 24.
    Sinniah R, Chur: Effect of IgA deposits on the glomerular mesangium in Berger’s disease. Ultrastruct Pathol 4:9–22, 1983.PubMedCrossRefGoogle Scholar
  25. 25.
    Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan Y-L, Jackson B: IgA nephropathy: a syndrome of uniform morphology diverse clinical features and uncertain prognosis. Clin Nephrol 8:457–471, 1977.Google Scholar
  26. 26.
    Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G: Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schoenlein nephritis: correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239, 1982.PubMedGoogle Scholar
  27. 27.
    Lesavre P, Digeon M, Bach JF: Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48:61–69, 1982.PubMedGoogle Scholar
  28. 28.
    Doi T, Kanatsu K, Sekita K, Yoshida H, Nagai H, Hamashima Y: Detection of IgA class circulating immune complexes bound to anti-C3d antibody in patients with IgA nephropathy. J Immunol Methods 69:95–104, 1984.PubMedCrossRefGoogle Scholar
  29. 29.
    Egido J, Sancho J, Hernando P, Gonzalez J, Hernando L: Presence of specific IgA immune complexes in IgA nephropathy. Contrib Nephrol 40:80–86, 1984.PubMedGoogle Scholar
  30. 30.
    Rifai A, Small PA, Teague PO, Ayoub EM: Experimental IgA nephropathy. J Exp Med 150:1161–1173, 1979.PubMedCrossRefGoogle Scholar
  31. 31.
    Sancho J, Egido J, Rivera F, Hernando L: Immune complexes in IgA nephropathy: presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes. Clin Exp Immunol 54:194–202, 1983.PubMedGoogle Scholar
  32. 32.
    Tomino Y, Sakai H, Suga T, Miura M, Kaneshige H, Endoh, M, Nomoto Y: Impaired solubilization of glomerular immune deposits by sera from patients with IgA nephropathy. Am J Kidney Dis 3:48–54, 1983.PubMedGoogle Scholar
  33. 33.
    Tomino Y, Sakai H, Miura M, Suga T, Endoh M, Nomoto Y: Effect of danazol in solubilization of immune deposits in patients with I nephropathy. Am J Kidney Dis 4:135–140, 1984.PubMedGoogle Scholar
  34. 34.
    Woodroffe AJ, Gormly AA, Menzie PE, Wooton AM, Thompson AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–374, 1980.PubMedCrossRefGoogle Scholar
  35. 35.
    Nomoto Y, Sakai H: Cold reacting antinuclear factor in sera from patients with IgA nephropathy. J Lab Clin Med 74:76–87, 1979.Google Scholar
  36. 36.
    Cohen RS, Russell MT, Dickey LE, Schwartz MM, Roberts JL: Properties of IgA isolated from serum of patients with IgA glomerulopathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology. (1984, p 274A. New York: Springer-Verlag).Google Scholar
  37. 37.
    Chatenoud L, Bach MA: Abnormalities of T cell subsets in glomerulonephritis and systemic lupus erythematosus. Kidney Int 20:267–274, 1981.PubMedCrossRefGoogle Scholar
  38. 38.
    Bannister KM, Drew PA, Clarkson AR, Woodroffe AJ: Immunoregulation in glomerulonephritis, Henoch-Schönlein purpura and lupus nephritis. Clin Exp Immunol 53:384–390, 1983.PubMedGoogle Scholar
  39. 39.
    Egido J, Blasco R, Sancho J, Lozano L: T cell dysfunction in IgA nephropathy: specific abnormalities in the regulation of IgA synthesis. Clin Immunol Immunopathol 26:201–212, 1983.PubMedCrossRefGoogle Scholar
  40. 40.
    Nomoto Y, Sakai H, Arimori S: Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Pathol 71:158–160, 1979.PubMedGoogle Scholar
  41. 41.
    Sakai H, Endoh M, Tomino Y, Nomoto Y: Increase of IgA specific helper T cells in patients with IgA nephropathy. Clin Exp Immunol 50:77–82, 1982.PubMedGoogle Scholar
  42. 42.
    Hale GM, Bannister KM, Clarkson AR, Woodroffe AJ: Immunoregulatory abnormalities in IgA nephropathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology. New York: Springer-Verlag, 1984, p 281A.Google Scholar
  43. 43.
    Sakai H, Nomoto Y, Arimori S: Decrease of IgA-specific suppressor T cell activity in patients with I nephropathy. Clin Exp Immunol 38:243–248, 1979.PubMedGoogle Scholar
  44. 44.
    Beale MG, Nash GS, Bertovich MJ, Maermott RP: Similar disturbances in B cell activity and regulatory T cell function in Henoch-Schönlein purpura and systemic lupus erythematosus. J Immunol 128:486–491, 1982.PubMedGoogle Scholar
  45. 45.
    Perl SI, Wilkinson A, Williams DG: IgA and IgG production by lymphocytes in IgA glomerulonephritis. Kidney Int 28:856, 1985.CrossRefGoogle Scholar
  46. 46.
    Egido J, Blasco R, Lozano J, Sancho J, Garcia-Hoyo R: Immunological abnormalities in the tonsils of patients with IgA nephropathy: inversion in the ratio of IgA: IgG bearing lymphocytes and increased polymeric IgA synthesis. Clin Exp Immunol 57:101–106, 1984.PubMedGoogle Scholar
  47. 47.
    Berthoux FC, Gagne A, Sabatier JC, Ducret F, Le Petit JC, Marcellin M, Mercier B, Brizard CP: HLA-Bw35 and mesangial IgA glomerulonephritis. N Engl J Med 298:1034–1035, 1978.PubMedGoogle Scholar
  48. 48.
    Hiki Y, Kobayashi Y, Tateno S, Sada M, Kashiwagi N: Strong association of HLA-DR4 with benign IgA nephropathy. Nephron 32:222–226, 1982.PubMedCrossRefGoogle Scholar
  49. 49.
    McLean RH, Wyatt RJ, Julian BA: Complement phenotypes in glomerulonephritis: increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Hencoh-Schönlein purpura. Kidney Int 26:855–860, 1984.PubMedCrossRefGoogle Scholar
  50. 50.
    Egido J, Blasco R, Sancho J, Lozano L, Gutierrez-Millet V: Immunologic studies in a familial IgA nephropathy. Clin Exp Immunol 54:532–538, 1983.PubMedGoogle Scholar
  51. 51.
    Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ: Familial IgA nephropathy: evidence of an inherited mechanism of disease. N Engl J Med 312:202–208, 1985.PubMedCrossRefGoogle Scholar
  52. 52.
    Galla JH, Kohaut EC, Alexander R, Mestecky J: Racial differences in the prevalence of IgA-associated nephropathies. Lancet 2:522, 1984.PubMedCrossRefGoogle Scholar
  53. 53.
    Disney APS: Australian and New Zealand dialysis and transplant registry, 1984.Google Scholar
  54. 54.
    Hoover RG, Heikman S, Berger HM, Rebbe N, Lynch RG: Expansion of Fc receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma. J Clin Invest 67:308–311, 1981.PubMedCrossRefGoogle Scholar
  55. 55.
    Nicholls K, Kincaid-Smith P: Defective in vivo Fc- and C3b-receptor function in IgA nephropathy. Am J Kidney Dis 4:128–134, 1984.PubMedGoogle Scholar
  56. 56.
    Woodroffe AJ: IgA, glomerulonephritis and liver disease. Aust NZJ Med 11:109–111, 1981.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Andrew J. Woodroffe

There are no affiliations available

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