Skip to main content
SpringerLink
Log in
Book cover

IgA Nephropathy pp 157–175Cite as

The Role of Polymeric IgA in the Pathogenesis of IgA Nephropathy

  • Chapter

Part of the book series: Topics in Renal Medicine ((TIRM,volume 2))

Abstract

Primary IgA nephropathy is characterized by the presence of IgA at the mesangium level accompanied or not by other immunoglobulins in the absence of systemic liver disease. A similar immunofluorescence pattern has been observed in an array of diseases involving mucosal surfaces and the term syndrome of IgA nephropathy has been suggested [1].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Clarkson AR, Woodroffe AJ, Bannister KM, Lomax-Smith JD, Aarons I: The syndrome of IgA nephropathy. Clin Nephrol 21:7–14, 1984.

    PubMed  CAS  Google Scholar 

  2. Bienenstock J, Befus AD: Some thoughts on the biologic role of immunoglobulin A. Gastroenterology 84:178–185, 1983.

    PubMed  CAS  Google Scholar 

  3. Kutteh WH, Prince SJ, Mestecky J: Tissue origins of human polymeric and monomeric IgA. J Immunol 128:990–995, 1982.

    PubMed  CAS  Google Scholar 

  4. Egido J, Sancho J, Blasco R, Hernando L: Le rôle de 1’IgA polymerique dans la pathogenie de la néphropathie à IgA. Néphrologie 4:99–101, 1983.

    PubMed  CAS  Google Scholar 

  5. Egido J, Sancho J, Blasco R, Hernando L: Immunopathogenetic aspects of IgA nephropathy. Adv Nephrol 12:103–137, 1983.

    CAS  Google Scholar 

  6. Lagrue G, Hirbec G, Fournel M: Glomérulonéphritis à dépôts d’IgA: étude des IgA sériques. J Urol Nephrol 80:385–389, 1974.

    CAS  Google Scholar 

  7. Berger J. Yaneva H, Nabarra B, Barbanel C: Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7:232–245, 1975.

    Article  PubMed  CAS  Google Scholar 

  8. Lopez-Trascasa M, Egido J, Sancho J, Hernando L: Evidence of high polymeric IgA levels in serum of patients with Berger’s disease: its modification with phenytoin treatment. Proc Eur Dial Transplant assoc 16:513–519, 1979.

    Google Scholar 

  9. Lopez Trascasa M, Egido J, Sancho J, Hernando L: IgA glomerulonephritis (Berger’s disease): evidence of high serum levels of polymeric IgA. Clin Exp Immunol 42:247–254.

    Google Scholar 

  10. Egido J, Sancho J, Mampaso F, Lopez Trascasa M, Sanchez Crespo M, Blasco R, Hernando L: A possible common pathogenesis of the mesangial IgA glomerulonephritis in patients with Berger’s disease and Schönlein-Henoch syndrome. Proc Eur Dial Transplant Assoc 17:660–666, 1980.

    PubMed  CAS  Google Scholar 

  11. Sancho J, Egido J, Sanchez Crespo M, Blasco R: Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease. Clin Exp Immunol 47:327–335, 1982.

    PubMed  CAS  Google Scholar 

  12. Valentijn RM, Radl J, Haaijman JJ, Vermeer BJ, Weening JJ, Kauffmann RH, Daha MR, Van Es LA: Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy. Kidney Int 26:760–766, 1984.

    Article  PubMed  CAS  Google Scholar 

  13. Bernasconi P, Sinico RA, Fornasieri A, Castiglione A, D’Amico G: IgA-immune complexes and polymeric IgA in IgA nephropathy. In: Mucosal Immunity, J.P. Revillard, C. Voisin, N. Wierzbicki (eds) pp. 298–299, Paris, 1984.

    Google Scholar 

  14. Woodroffe AJ, Gormly AA, McKenzie DE, Wooton AM, Thompson AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–374, 1980.

    Article  PubMed  CAS  Google Scholar 

  15. Lesavre Ph, Digeon M, Bach JF: Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48:61–69, 1982.

    PubMed  CAS  Google Scholar 

  16. Newkirk MM, Klein MH, Katz A, Fisher MM, Underdown BJ: Estimation of polymeric IgA in human serum: an assay based on binding of radiolabeled human secretory component with applications in the study of IgA nephropathy, IgA monoclonal gammapathy, and liver disease. J Immunol 130:1176–1181, 1983.

    PubMed  CAS  Google Scholar 

  17. Berger J: IgA mesangial nephropathy 1968–1983. Contrib Nephrol 40:4–6, 1984.

    PubMed  CAS  Google Scholar 

  18. Feehally: Discussion on immune system abnormalities in idiopathic IgA nephropathy in “IgA mesangial nephropathy.” Contrib Nephrol 40:142, 1984.

    Google Scholar 

  19. Egido J, Sancho J, Blasco R, Lozano L, Hernando L: Immunologic aspects of IgA nephropathy in humans. In: Robinson RR (ed) Nephrology, vol 1: proceedings of the 9th international congress on nephrology. New York: Springer-Verlag, 1984, pp 652–664.

    Google Scholar 

  20. Sancho J, Egido J, Gonzalez E: A simplified method for determining polymeric IgA-containing immune complexes. J Immunol Methods 60:305–317, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Egido J, Sancho J, Hernando P, Gonzalez J, Hernando L: The presence of specific IgA immune complexes in IgA nephropathy. Contrib Nephrol 40:85–87, 1984.

    Google Scholar 

  22. Egido J, Sancho J, Rivera F, Hernando L: The role of IgA and IgG immune complexes in IgA nephropathy. Nephron 36:59–66, 1984.

    Article  Google Scholar 

  23. Doi T, Kanatsy K, Sekita K, Yoshida H, Nagai H, Hamashima Y: Detection of IgA class circulating immune complexes bound to anti C3d antibody in patients with IgA nephropathy. J Immunol Methods 69:95–104, 1984.

    Article  PubMed  CAS  Google Scholar 

  24. Rifai A, Small PA, Teague PO, Ayurb EM: Experimental IgA nephropathy. J Exp Med 150:1161–1173, 1979.

    Article  PubMed  CAS  Google Scholar 

  25. Rifai A, Millar K, Verani R: IgA molecular form nephritogenicity correlates immune complex formation and glomerular deposition. Kidney Int 27:221 A, 1985.

    Google Scholar 

  26. Czerkinsky C, Crago SS, Koopman WJ, Jackson S, Schrohenloher RE, Galla J, Mestecky J: The occurrence of circulating IgA-IgG immune complexes in IgA nephropathy. In: Mucosal Immunity, J.P. Revillard, C. Voisin, N. Wierzbicki (eds) pp. 295–297, Paris, 1984.

    Google Scholar 

  27. González Cabrero J., Egido J, Sancho J, Moldenhauer F.: Presence of shared idiotypes in serum and immune complexes in patients with IgA nephropathy. Clin Exp Immunol 1987 (in press).

    Google Scholar 

  28. Germuth FG, Rodriguez E, Lorelle CA, Trump EI, Milano L, Wise OL: Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. I. High avidity complexes and mesangiopathic glomerulonephritis. Lab Invest 41:360–365, 1979.

    PubMed  Google Scholar 

  29. Monteiro RC, Halbwachs-Mecarelli L, Berger J, Lesavre P: Characteristics of eluted IgA in primary IgA nephropathy. Contrib Nephrol 40:107–111, 1984.

    PubMed  CAS  Google Scholar 

  30. Border WA: Role of antigen and antibody charge in immune complex disease. In: Robinson RR (ed) Nephrology, vol 1: proceedings of the 9th international congress on nephrology, Los Angeles, pp 550–559.

    Google Scholar 

  31. Russel-Jones GJ, Gotschlich EC, Blake MS: A surface receptor specific for human IgA on group B streptococci possessing the Ibc protein antigen. J Exp Med 160:1467–1475, 1984.

    Article  Google Scholar 

  32. Dobrin RS, Knudson FE, Michael AF: The secretory immune system and renal disease. Clin Exp Immunol 21:318–328, 1975.

    PubMed  CAS  Google Scholar 

  33. Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour AE, Woodroffe AJ: The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113:359–364, 1983.

    PubMed  CAS  Google Scholar 

  34. Brandtzaeg P: Characteristics of SC-IgA complexes formed in vitro. Adv Exp Med Biol 45:87–93, 1974.

    PubMed  CAS  Google Scholar 

  35. Bene MC, Faure G, Duheille J: IgA nephropathy: characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component. Clin Exp Immunol 47:527–534, 1982.

    PubMed  CAS  Google Scholar 

  36. Tornino Y, Sakai M, Miura M, Endoh M, Nomoto Y: Detection of polymeric IgA in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419–425, 1982.

    Google Scholar 

  37. Donini V. Casanova S, Zimi N, Zucchelli P: The presence of J-chain in mesangial immune deposits of IgA nephropathy. Proc Eur Dial Transplant Assoc 19:655–661, 1982.

    Google Scholar 

  38. Komatsu N, Nagura H, Watanabe K, Nomoto Y, Kobayashi K: Mesangial deposition of J-chain-linked polymeric IgA in IgA nephropathy. Nephron 33:61–64, 1983.

    Article  PubMed  CAS  Google Scholar 

  39. Waldherr R, Seelig HP, Rambausek M, Andrassy K, Ritz E: Deposition of polymeric IgAl in idiopathic mesangial IgA: glomerulonephritis. Klin Wochenschr 61:911–915, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Emancipator S, Gallo G, Lamm M: Experimental IgA nephropathy induced by oral immunization. J Exp Med 157:572–582, 1983.

    Article  PubMed  CAS  Google Scholar 

  41. Gallo GR, Emancipator SN, Lamm ME: Experimental cholestasis and deposition of glomerular IgA immune complexes. Contrib Nephrol 40:55–61, 1984.

    PubMed  CAS  Google Scholar 

  42. André C, Berthoux C, André F, Guillon J, Genin C, Sabatier JC: Prevalence of IgA2 deposits in IgA nephropathy: a clue for their pathogenesis. N Engl J Med 303:1343–1346, 1980.

    Article  PubMed  Google Scholar 

  43. Conley ME, Cooper MD, Michael AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis and systemic lupus erythematosus. J Clin Invest 66:1432–1436, 1980.

    Article  PubMed  CAS  Google Scholar 

  44. Hall RP, Stachura I, Cason J, Whiteside TL, Lawley TL: IgA-containing circulating immune complexes in patients with IgA nephropathy. Am J Med 74:56–63, 1983.

    Article  PubMed  CAS  Google Scholar 

  45. Murakami T, Furuse A, Hattori S, Kobayashi K, Matsuda J: Glomerular IgAl and IgA2 deposits in IgA nephropathies. Nephron 35:120–123, 1983.

    Article  PubMed  CAS  Google Scholar 

  46. Delacroix DL, Liroux E, Vaerman JP: High proportion of polymeric IgA in young infant’s sera and independence between IgA-size and IgA subclass distributions. J Clin Immunol 3:53–58, 1983.

    Article  Google Scholar 

  47. Rifai A, Mannik M: Clearance kinetics and fate of mouse IgA immune complexes prepared with monomeric or dimeric IgA. J Immunol 130:1826–1832, 1983.

    PubMed  CAS  Google Scholar 

  48. Sancho J, Gonzalez E, Rivera F, Escanero JF, Egido J: Hepatic and kidney uptake of soluble monomeric and polymeric IgA aggregates. Immunology 52:161–167, 1984.

    PubMed  CAS  Google Scholar 

  49. Kutteh WH, Koopman WJ, Conley ME, Egan ML, Mestecky J: Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens. J Exp Med 152:1424–1427, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Egido J, Blasco R, Sancho J, Lozano L, Sanchez Crespo M, Hernando L: Increased rates of polymeric IgA synthesis by circulating lymphoid cells in IgA mesangial glomerulonephritis. Clin Exp Immunol 47:309–316, 1982.

    PubMed  CAS  Google Scholar 

  51. Beukhof JR, Ockhnizen Th, Halie LM, Westra J, Belen JM, Donker AJM, Hoedemaeker Ph J, Van der Hem GK: Subentities within adult primary IgA nephropathy. Clin Nephrol 22:195–199, 1984.

    PubMed  CAS  Google Scholar 

  52. Egido J, Blasco R, Lozano L, Sancho J, Garcia Hoyo R: Immunological abnormalities in tonsils of patients with IgA nephropathy inversion in the percentage of IgA versus IgG bearing lymphocytes and increased polymeric IgA synthesis. Clin Exp Immunol 57:101–106, 1984.

    PubMed  CAS  Google Scholar 

  53. Lozano L, Garcia Hoyo R, Blasco R, Sancho J, Egido J: Effect of tonsillectomy on polymeric IgA synthesis by blood lymphocytes in patients with IgA nephropathy. Eur J Clin Invest 15, A40, 1985.

    Google Scholar 

  54. Lum LG, Muchmore AV, Keren D, Decker J, Koski I, Strober W, Blaese RM: A receptor for IgA on human T lymphocytes. J Immunol 122:65–69, 1979.

    PubMed  CAS  Google Scholar 

  55. Sakai H, Endoh M, Tomino Y, Nomoto Y: Increase of IgA specific helper Ta cells in patients with IgA nephropathy. Clin Exp Immunol 50:77–82, 1982.

    PubMed  CAS  Google Scholar 

  56. Endoh M, Sakai H, Nomoto Y, Tomino Y, Kaneshige H: IgA-specific helper activity of Ta cells in human peripheral blood. J Immunol 127:2612–2613, 1981.

    PubMed  CAS  Google Scholar 

  57. Adachi M, Yodoi J, Masuda T, Takatsuki K, Uchino H: Altered expression of lymphocyte Fca receptor in selective IgA deficiency and IgA nephropathy. J Immunol 131:1246–1251, 1983.

    PubMed  CAS  Google Scholar 

  58. Egido J, Blasco R, Sancho J, Lozano L: T-cell dysfunctions in IgA nephropathy: specific abnormalities in the regulation of IgA synthesis. Clin Immunol Immunopathol 26:201–2 1983.

    Article  PubMed  CAS  Google Scholar 

  59. Egido J, Sancho J, Rivera F, Sanchez Crespo M: Handling of soluble IgA aggregates by the mononuclear phagocytic system in mice: a comparison with IgG aggregates. Immunology 46:1–7, 1982.

    PubMed  CAS  Google Scholar 

  60. Peppard J, Orlans E, Payne AWR, Andrew E: The elimination of circulating complexes containing polymeric IgA by excretion in the bile. Immunology 42:83–89, 1981.

    PubMed  CAS  Google Scholar 

  61. Sancho J, Gonzalez E, Egido J: Handling of IgA immune aggregates by liver cells. Contrib Nephrol 40:93–98, 1984.

    PubMed  CAS  Google Scholar 

  62. Sancho J, Gonzalez E, Egido J: The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with the carbohydrate and secretory component receptors. Immunology 57:37–42, 1986.

    PubMed  CAS  Google Scholar 

  63. Russell MW, Brown TA, Claffin JL, Schroer K, Mestecky J: Immunoglobulin A mediated hepatobiliary transport constitutes a natural pathway for disposing of bacterial antigens. Infect Immun 42:1041–1048, 1983.

    PubMed  CAS  Google Scholar 

  64. Sancho J, Egido J, Rivera F, Hernando L: Immune complexes in IgA nephropathy: presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes. Clin Exp Immunol 54:104–111, 1983.

    Google Scholar 

  65. Lawrence S, Pussell BA, Charlesworth JA: Mesangial IgA nephropathy: detection of defective reticulophagocytic function in vivo. Clin Nephrol 16:280–283, 1983.

    Google Scholar 

  66. Bannister KM, Hay J, Clarkson AR, Woodroffe AJ: Fc-specific reticulo-endothelial clearance in systemic lupus erythematosus and glomerulonephritis. Am J Kidney Dis 3:287–292, 1984.

    PubMed  CAS  Google Scholar 

  67. Sato M, Kinugasa E, Ideura T, Koshikawa S: Phagocytic activity of polymorphonuclear leukocytes in patients with IgA nephropathy. Clin Nephrol 19:166–171, 1983.

    PubMed  CAS  Google Scholar 

  68. Unsworth DJ, Leonard JN: IgA in dermatitis herpetiformis skin is dimeric. Lancet 27:479–481, 1982.

    Google Scholar 

  69. Lawley TJ: Reticuloendothelial system function, p 863. In: Katz SI (moderator) dermatitis herpetiformis: the skin and the gut. Ann Intern Med 93:857–869, 1980.

    Google Scholar 

  70. Wilton JMA: Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leukocytes. Clin Exp Immunol 34:423–428, 1978.

    PubMed  CAS  Google Scholar 

  71. Egido J, Sancho J, Lorente F, Fontan G: Inhibition of neutrophil migration by serum from patients with IgA nephropathy. Clin Exp Immunol 49:709–716, 1982.

    PubMed  CAS  Google Scholar 

  72. Gonzalez E, Sancho J, Gonzalez J, Blasco R, Garcia Hoyo R, Lozano L, Egido J, Hernando L: IgA nephropathy in mice: mechanisms involved in the deposition of IgA in the mesangium. Eur J Clin Invest 15:A46, 1985.

    Google Scholar 

  73. Moldoveanu Z, Egan ML, Mestecky J: Cellular origins of human polymeric and monomeric IgA: intracellular and secreted forms of IgA. J Immunol 133:3156–3162, 1984.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Jesus Egido
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Anthony R. Clarkson

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijihoff Publishing, Boston

About this chapter

Cite this chapter

Egido, J. (1987). The Role of Polymeric IgA in the Pathogenesis of IgA Nephropathy. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2039-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9213-5

  • Online ISBN: 978-1-4613-2039-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation