Intracerebral Transplantation as a Model for Studying the Myelination Process

  • Madeleine Gumpel
  • François Lachapelle
  • Michel Baulac
  • Annick Baron-Van Evercooren
  • Annie Gansmuller
  • Claude Jacque
  • Nicole Baumann


Early studies on myelination performed most often in the human brain clearly established that myelination does not proceed in all parts of the nervous system at the same time. It seems to follow the order of phylogenic development: portions of peripheral nervous system (PNS) myelinate first, then the spinal cord, and then the brain (reviewed by Norton, 1982). In the brain, myelination proceeds caudorostrally. In the human central nervous system (CNS), the process starts around the fifth month of intrauterine development in the motor roots (Yakovlev and Lecours, 1967) and continues for a long time since it is assumed that the intracortical associative areas are fully myelinated only 20 years later. Because of this lengthy developmental period in humans the myelination process has been extensively studied in small animal models like mouse or rat. In these models, myelin deposition occurs postnatally in the brain so that it is possible to follow the whole process for a short period of the animal’s life. The maturation of glial cell lines and the different steps of myelin formation in these animal models have been studied simultaneously by morphologists and biochemists (reviewed by Webster et al., 1981). The development of microchemical methods allowed two distinct and interesting approaches. First it has been possible to analyze the different constituents of myelin and to study their sequential deposition in the myelin sheath.


Schwann Cell Olfactory Bulb Myelin Basic Protein Glial Cell Line Transplantation Technique 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Madeleine Gumpel
  • François Lachapelle
  • Michel Baulac
  • Annick Baron-Van Evercooren
  • Annie Gansmuller
  • Claude Jacque
  • Nicole Baumann

There are no affiliations available

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