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In Vitro Model of Neuronal Aging and Development in the Nervous System

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Model Systems of Development and Aging of the Nervous System

Abstract

There is ample support for the hypothesis that free radical molecules play a major role in aging (Harman, 1981; Pryor, 1984; Packer, 1984; Cutler, 1985). This is also true for the pathological changes associated with aging brain (Agranoff, 1984; Cutler, 1985) although the bulk of studies on free radical processes in the nervous system have focused on acute neural tissue injury (Demopoulos et al., 1979; Naftchi and Gennaro, 1985; Willmore et al., 1983; Chan et al., 1984; Anderson and Means, 1985; Anderson et al., 1985). Although the relative contributions of the different components of auto-oxidation events are not fully resolved at the chemical level [see Aust et al. (1985) and Halliwell and Gutteridge (1985) for two views], there is little doubt that lipid peroxidation events, irrespective of the sources of catalysis, and endogenous levels of “scavenging enzymes” are predictive of pathological consequences. Given the cellular heterogeneity and level of intercellular communication peculiar to the nervous system, there are advantages to the development and use of an in vitro system where pertinent variables can be controlled.

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Authors
  1. Regino Perez-Polo
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  2. Karin Werrbach-Perez
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Editor information

Editors and Affiliations

  1. Departments of Psychiatry and Pharmacology, University of Colorado School of Medicine, 4200 East 9th Avenue, 80262, Denver, CO, USA

    Antonia Vernadakis

  2. Neurobiologie du Développement, INSERM U249, F-34060, Montpellier Cedex, France

    Alain Privat

  3. Department of Anatomy, University of North Carolina School of Medicine, 27514, Chapel Hill, NC, USA

    Jean M. Lauder

  4. Department of Physiology-Anatomy, University of California, 94720, Berkeley, CA, USA

    Paola S. Timiras

  5. Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 3926, 62708, Springfield, IL, USA

    Ezio Giacobini

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© 1987 Martinus Nijhoff Publishing, Boston

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Perez-Polo, R., Werrbach-Perez, K. (1987). In Vitro Model of Neuronal Aging and Development in the Nervous System. In: Vernadakis, A., Privat, A., Lauder, J.M., Timiras, P.S., Giacobini, E. (eds) Model Systems of Development and Aging of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2037-1_28

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  • DOI: https://doi.org/10.1007/978-1-4613-2037-1_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9212-8

  • Online ISBN: 978-1-4613-2037-1

  • eBook Packages: Springer Book Archive

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