Metabolic Regulation in Brain Cells

  • J. Tyson Tildon
  • Lois M. Roeder


Recent studies of metabolic regulation in brain have focused on the complexity and fine-tuning involved in the control of metabolic processes. Gaps in our knowledge are rapidly being filled as previously unidentified “factors” are purified and characterized, new compounds are identified, and new functions for familiar compounds are discovered. Often new information is obtained initially from tests of substances that support survival and growth of neural tissue in vitro, and the mechanisms involved are not fully investigated until much later. Such studies also have revealed the importance of cell-cell interactions (Mandel et al., 1977; Seeds and Hawkins, 1985), and several workers have identified specific metabolic processes involved in these exchanges (Cummins et al., 1979; Hertz, 1979; Pentreath and Kai-Kai, 1982; Sykora, 1983; Hertz and Richardson, 1984). Different factors seem to be involved in central nervous system (CNS) and peripheral nervous system (PNS) (Seifert and Muller, 1984). However, nerve growth factor (NGF), which is essential for the survival, both in vivo and in vitro, of sympathetic and sensory neurons (Levi-Montalcini and Angeletti, 1968) may also have a role in brain (Honegger and Lenoir, 1982). The proposed mechanisms of the neurotrophic action of NGF (and of some new putative growth factors) were recently reviewed by Thoenen and Edgar (1985). Kauffman and coworkers have begun to identify some of the specific metabolic alterations that accompany the growth effect of NGF on the superior cervical ganglion (Dumbrowski et al., 1983).


Thyroid Hormone Nerve Growth Factor Brain Cell Ketone Body Metabolic Regulation 
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© Martinus Nijhoff Publishing, Boston 1987

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  • J. Tyson Tildon
  • Lois M. Roeder

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