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Are Age-Related Changes in Receptor Activity an Expression of Altered Membrane Fluidity?

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Model Systems of Development and Aging of the Nervous System

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Abstract

Among the various theories of aging, the membrane hypothesis of aging is particularly appealing (Sun and Sun, 1979; Grinna, 1977). Cellular membranes function in mediating and regulating active transport of substances across the cell boundary as well as serving as an important permeability barrier. Enzyme activities and receptor functions are also modulated by the lipid composition of membranes. The nature of membranes may change during aging either as a result of oxidative damage (Tappel, 1973) or from a deterioration of homeostatic mechanisms that maintain proper lipid composition (Kates and Kuksis, 1980). In vitro and in vivo manipulation of membrane lipids may thus provide a model of aging.

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Authors
  1. Kern Von Hungen
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  2. Claude F. Baxter
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Editor information

Editors and Affiliations

  1. Departments of Psychiatry and Pharmacology, University of Colorado School of Medicine, 4200 East 9th Avenue, 80262, Denver, CO, USA

    Antonia Vernadakis

  2. Neurobiologie du Développement, INSERM U249, F-34060, Montpellier Cedex, France

    Alain Privat

  3. Department of Anatomy, University of North Carolina School of Medicine, 27514, Chapel Hill, NC, USA

    Jean M. Lauder

  4. Department of Physiology-Anatomy, University of California, 94720, Berkeley, CA, USA

    Paola S. Timiras

  5. Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 3926, 62708, Springfield, IL, USA

    Ezio Giacobini

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© 1987 Martinus Nijhoff Publishing, Boston

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Von Hungen, K., Baxter, C.F. (1987). Are Age-Related Changes in Receptor Activity an Expression of Altered Membrane Fluidity?. In: Vernadakis, A., Privat, A., Lauder, J.M., Timiras, P.S., Giacobini, E. (eds) Model Systems of Development and Aging of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2037-1_24

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  • DOI: https://doi.org/10.1007/978-1-4613-2037-1_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9212-8

  • Online ISBN: 978-1-4613-2037-1

  • eBook Packages: Springer Book Archive

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