Do Mouse Cerebellum Astrocytes Play a Role in Neuronal Survival and Differentiation?

  • Bernard Pessac
  • Françoise Alliot


The cerebellum is a region of the central nervous system (CNS) that has often been used as a model because of the well-studied development, circuitry, and properties of its few neuronal cell types (Eccles et al., 1967; Palay and Chan-Palay, 1974). It has been proposed that, in cerebellum, some astroglial cells have an architectonic role. Indeed, during late embryonic development, the Golgi epithelial cells, whose bodies are located in the Purkinje cell layer, extend radial astroglial processes, the Bergmann fibers, to the pial surface of the cerebellum cortex, probably to guide the migration of granule cell neurons from the ventricular zone to the external granular layer (Rakic, 1971; De Bias, 1984). In addition, the astroglia organizes postmitotic mature neurons into compartments; in particular there is evidence that the processes of the velate protoplasmic astrocytes form septa that wall off lamellar, veil-like compartments that contain groups of granule cell bodies (Palay and Chan-Palay, 1974).


Granule Cell Neuronal Survival Astroglial Cell Tetanus Toxin Mouse Cerebellum 
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© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Bernard Pessac
  • Françoise Alliot

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