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Cell Culture Systems for Purified Retinal Neurons and Photoreceptors

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Model Systems of Development and Aging of the Nervous System

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Abstract

Many of the cellular mechanisms that are particularly conspicuous during embryonic development are also prevalent in the adult, either under normal circumstances or in specific pathological conditions. For example, many of the severe degenerative disorders known to affect the adult nervous system involve selective neuronal death, thus resembling the phenomenon of developmental neuronal death that occurs in the embryo (Appel, 1981; Varon and Adler, 1980). Neurological deficits can also result from failures in the development or maintenance of the differentiated functions typical of nerve cells. Both types of degeneration are known to occur in the neural retina and often lead to blindness (c.f. Adler, 1986a). Thus, detailed knowledge of the molecular mechanisms that regulate neuronal survival and differentiation is important for understanding not only normal development but also pathological alterations of the nervous system in general and the retina in particular.

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Authors
  1. Ruben Adler
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Editor information

Editors and Affiliations

  1. Departments of Psychiatry and Pharmacology, University of Colorado School of Medicine, 4200 East 9th Avenue, 80262, Denver, CO, USA

    Antonia Vernadakis

  2. Neurobiologie du Développement, INSERM U249, F-34060, Montpellier Cedex, France

    Alain Privat

  3. Department of Anatomy, University of North Carolina School of Medicine, 27514, Chapel Hill, NC, USA

    Jean M. Lauder

  4. Department of Physiology-Anatomy, University of California, 94720, Berkeley, CA, USA

    Paola S. Timiras

  5. Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 3926, 62708, Springfield, IL, USA

    Ezio Giacobini

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© 1987 Martinus Nijhoff Publishing, Boston

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Adler, R. (1987). Cell Culture Systems for Purified Retinal Neurons and Photoreceptors. In: Vernadakis, A., Privat, A., Lauder, J.M., Timiras, P.S., Giacobini, E. (eds) Model Systems of Development and Aging of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2037-1_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2037-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9212-8

  • Online ISBN: 978-1-4613-2037-1

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