Abstract
Although the otolaryngologist treats mainly cancers of squamous histology, non-Hodgkin’s lymphomas represent a substantial number of newly diagnosed head and neck cancers [1, 2]. Cervical adenopathy is one of the most common presenting signs of non-Hodgkin’s lymphomas, but up to 10% of patients present with lymphomas in extranodal head and neck sites — Waldeyer’s ring or other extralymphatic sites, including oral cavity, larynx, salivary gland, paranasal sinus, thyroid, and orbit. The signs and symptoms of a non-Hodgkin’s lymphoma in an extranodal head and neck site may be similar to those of a head and neck squamous cancer, and only by biopsy can the distinction be made. However, occasionally a pathologist will have difficulty distinguishing between a poorly differentiated carcinoma and a non-Hodgkin’s lymphoma. Newer immunohistologic techniques have been helpful in making this distinction. The histologic classification of the non-Hodgkin’s lymphomas has undergone recent change, and familiarity with the currently used classification systems is important in understanding the natural history and expected outcome of patients with lymphomas. Based on retrospective analysis of series of patients with extranodal and neck lymphomas at various institutions, appropriate staging procedures can be recommended. Finally, the therapy of the non-Hodgkin’s lymphomas is rapidly changing, and survival data continue to improve. The recommended optimal therapy varies with histology, stage of disease, and head and neck site. This review will cover the presentation, histology, staging and treatment of extranodal head and neck lymphomas.
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References
Bonadonna, G., Molinari, R., Banfi, A. 1981. Hodgkin and non-Hodgkin lymphoma presenting in the head and neck. In: Cancer of the Head and Neck (J.Y. Suen, E.N. Myers, eds.). Churchill Livingstone, New York.
Schnitzer, B., Weaver, D.K. 1979. Lymphoreticular disorders. In: Tumors of the Head and Neck (J.G. Batsakis, ed.). Williams and Wilkins Co, Baltimore.
Jacobs, C., Hoppe, R.T. 1985. Non-Hodgkin’s lymphomas of head and neck extranodal sites. Int. J. Radiat. Oncol. Biol. Phys. 11: 357–364.
Hoppe, R.T., Burke, J.S., Glatstein, E., Kaplan, H.S. 1978. Non-Hodgkin’s lymphoma. Involvement of Waldeyer’s ring. Cancer 42: 1096–1104.
Bajetta, E., Buzzoni, R., Rilke, F., Valagussa, P. et al. 1983. Non-Hodgkin’s lymphomas of Waldeyer’s ring. Tumori 69: 129–136.
Brugere, J., Schlienger, M., Gerard-Marchant, R. et al. 1975. Non-Hodgkin’s malignant lymphomata of upper digestive and respiratory tract: Natural history and result of radiotherapy. Br. J. Cancer 31: 435–440.
Plantenga, K.F., Hart, G., van Heerde, P., Tierie, A.H. 1981. Non-Hodgkin’s malignant lymphomas of upper digestive and respiratory tracts. Int. J. Radiat. Oncol. Biol. Phys. 7: 1419–1427.
Shimm, D.S., Dosorets, D.E., Harris, N.L. et al. 1984. Radiation therapy of Waldeyer’s ring lymphoma. Cancer 54: 426–431.
Mill, W.B., Lee, F.A., Franssila, K.O. 1980. Radiation therapy treatment of stage I and II extranodal non-Hodgkin’s lymphoma of the head and neck. Cancer 45: 653–661.
Wang, C.C. 1969. Malignant lymphoma of Waldeyer’s ring. Radiology 92: 1335–1339.
Wong, D.S., Fuller, L.M., Butler, J.J., Schullenberger, C.C. 1975. Extranodal non-Hodgkin’s lymphomas of the head and neck. A.J.R. 123: 471–481.
Fitzpatrick, P.J., Macko, S. 1984. Lymphoreticular tumors of the orbit. Int. J. Radiat. Oncol. Biol. Phys. 10: 333–340.
Blair, T.J., Evans, R.G., Buskirk, S.J. et al. 1985. Radiotherapeutic management of primary thyroid lymphomas. Int. J. Radiat. Oncol. Biol. Phys. 11: 365–370.
Hamburger, J.I., Miller, J.M., Kini, S.R. 1983. Lymphoma of the thyroid. Ann. Intern. Med. 99: 685–693.
Fierstein, J.T., Thawley, S.E. 1970. Lymphoma of the head and neck. Laryngoscope 88: 582–593.
Clark, R.M., Fitzpatrick, P.J., Gospodarowicz, M.K. 1983. Extranodal malignant lymphomas of the head and Neck. J. Otolaryngol. 4: 239–245.
Shidnia, H., Hornback, N.B., Lingeman, R., Barlow, P. 1985. Extranodal lymphoma of the head and neck area. Am. J. Clin. Oncol. 8: 235–243.
Clark, L.Y., Hoppe, R.T., Burke, J.S., Kaplan, H.S. 1981. Non-Hodgkin’s lymphoma presenting as thyroid enlargement. Cancer 48: 2712–2716.
Kim, Y.H., Fayos, H.V. 1976. Primary orbital lymphoma: A radiotherapeutic experience. Int. J. Radiat. Oncol. Biol. Phys. 1: 1099–1105.
Rappaport, H. 1966. Tumors of the hematopoetic system. In: Atlas of Tumor Pathology, Section III, Fascicle 9. Armed Institute of Pathology, Washington, DC.
Jones, S.E., Fuks, Z., Bull, M. et al. 1973. Non-Hodgkin’s lymphomas IV. Clinicopathologic correlation in 405 cases. Cancer 31: 806–823.
Nathwani, B.N., Kim, H., Rappaport, H. 1976. Malignant lymphoma, lymphoblastic. Cancer 38: 964–983.
Ziegler, J.L., 1979. Management of Burkitt’s lymphoma: an update. Cancer Treat. Rev. 6: 95–105.
Horiuchi, J., Okuyama, T., Matsubara, S. et al. 1982. Extranodal non-Hodgkin’s lymphoma in the head and neck: Irradiation and clinical course. Acta Radiol. Oncol. 21: 383–399.
Burke, J.S., Butler, J.J., Fuller, L.M. 1977. Malignant lymphomas of the thyroid. Cancer 39: 1587–1602.
Bennett, C.L., Patterman, A., Bitran, J.D. et al. 1986. Staging and therapy of orbital lymphomas. Cancer 57: 1204–1208.
Jereb, B., Lee, H., Jakobiec, F.A., Kutcher, J. 1984. Radiation therapy of conjunctival and orbital lymphoid tumors. Int. J. Radiat. Oncol. Biol. Phys. 19: 1013–1019.
Knowles, D.M., Jakobiec, F.A. 1980. Orbital lymphoid neoplasms: A clinicopathologic study of 60 patients. Cancer 46: 576–589.
The Non-Hodgkin’s Lymphoma Pathologic Classification Project. 1982. National Cancer Institute sponsored study of non-Hodgkin’s lymphomas: Summary and description of a working formulation for clinical usage. Cancer 49: 2112–2135.
Lukes, R.J., Taylor, C.R., Parker, J.W., Lincoln, I.L. 1978. A morphologic and immunologic surface marker study of 299 cases of non-Hodgkin’s lymphomas and related leukemias. Am. J. Pathol. 90: 461–485.
Levy, R., Warnke, R., Dorfman, R.F., Haimovich, J. 1977. The monoclonality of human B-cell lymphomas. J. Exp. Med. 145: 1014–1028.
Weiss, L.M., Crabtree, G.S., Rouse, R.V., Warnke, R.A. 1985. Morphologic and immunologic characterization of 50 peripheral T cell lymphomas. Am. J. Pathol. 118: 316–324.
Warnke, R.A., Weiss, L.M. 1985. A practical approach to the immunodiagnosis of lymphomas emphasizing differential diagnosis. Cancer Surveys 4: 348–358.
Warnke, R.A., Gatter, K.C., Falini, B. et al. 1983. Diagnosis of human lymphoma with monoclonal anti-leukocyte antibodies. N. Engl. J. Med. 309: 1275–1281.
Fisher, R.I., Hubbard, S.M., Dita, V.T. et al. 1981. Factors predicting long-term survival in diffuse mixed, histiocytic, or undifferentiated lymphoma. Blood 58: 45–51.
Banfi, A., Bonadonna, G., Ricci, S.B. et al. 1972. Malignant lymphomas of Waldeyer’s ring: Natural history and survival after radiotherapy. Br. Med. J. 3: 140–143.
MacKintosh, F.R., Colby, T.V., Podolsky, W.J., Burke, J.S., Hoppe, R.T., Rosenfelt, F.P., Rosenberg, S.A., Kaplan, H.S. 1982. Central nervous system involvement in non-Hodgkin’s lymphoma: an analysis of 105 cases. Cancer 49: 586–595.
Bunn, P.A., Schein, P.S., Banks, P.M., Dita, V.T. 1976. Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisted. Blood 47: 3–10.
Carbone, P.P., Kaplan, H.S., Musshoff, K., Smithers, D.W., Tubiana, M. 1971. Report of the committee on Hodgkin’s disease staging classification. Cancer Res. 31: 1860–1861.
Austin-Seymour, M.M., Donaldson, S.S., Egbert, P.R. et al. 1985. Radiotherapy of lymphoid diseases of the orbit. Int. J. Radiat. Oncol. Biol. Phys. 11: 371–379.
Lazzarino, M., Morra, E., Rosso, R. et al. 1985. Clinicopathologic and immunologic characteristics of non-Hodgkin’s lymphomas presenting in the orbit. Cancer 55: 1907–1912.
Miller, T.P., Jones, S.E. 1983. Initial chemotherapy for clinically localized lymphomas of unfavorable histology. Blood 62: 413–418.
McKelvey, E.M., Gottlieb, J.A., Wilson, H.E. et al. 1976. Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38: 1484–1493.
Skarin, A.T., Canellos, G.P., Rosenthal, D.S. et al 1983. Improved prognosis of diffuse histiocytic and undifferentiated lymphoma by use of high dose methotrexate alternating with standard agents (M-BACOD). J. Clin. Oncol. 1: 91–98.
Coleman, C.N., Cohen, J.R., Burke, J.S., Rosenberg, S.A. 1981. Lymphoblastic lymphoma in adults: Result of a pilot protocol. Blood 4: 679–684.
Paryani, S.B., Hoppe, R.T., Cox, R.S., Colby, T.V., Rosenberg, S.A., Kaplan, H.S. 1983. Analysis of non-Hodgkin’s lymphomas with nodular and favorable histologies, stages I and II. Cancer 52: 2300–2307.
Monfardini, S., Banfi, A., Bonadonna, G. et al. 1980. Improved five-year survival after combined radiotherapy-chemotherapy for stage I-II non-Hodgkin’s lymphoma. Int. J. Radiat. Oncol. Biol. Phys. 6: 125–134.
Rosenberg, S.A., 1979. Non-Hodgkin’s lymphoma – selection of treatment on the basis of histologic type. N. Engl. J. Med. 301: 924–928.
Portlock, C.S., Rosenberg, S.A. 1977. Chemotherapy of the non-Hodgkin’s lymphomas: the Stanford experience. Cancer Treat. Rep. 61: 1049–1055.
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© 1987 Martinus Nijhoff Publishers, Boston
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Jacobs, C. (1987). Lymphomas of extranodal head and neck sites. In: Jacobs, C. (eds) Cancers of the Head and Neck. Cancer Treatment and Research, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2029-6_16
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DOI: https://doi.org/10.1007/978-1-4613-2029-6_16
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