Abstract
Steroid hormone action in specific target cells has been under intense study for the last three decades. Refinements in the technique of radioreceptor assay combined with the availability of radio-labeled steroid analogues have increased the precision and sensitivity in the measurement of hormone receptors. These assays were first used as clinical adjuvants in breast and prostate malignancies which are thought of as hormone ‘responsive’. In parallel with studies of breast carcinoma, quantification of cytosolic estrogen receptors (ERc) and cytosolic progesterone receptors (PRc) in endometrial carcinoma has been touted as an prognostic index [1–5]. In addition, association of receptor quantity with response to hormone treatment in endometrial carcinoma has been documented [1, 6].
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References
Creasman WT, McCarty KS Sr, Barton TK, McCarty KS Jr. 1980. Clinical correlates of estrogen and progesterone-binding proteins in human endometrial adenocarcinoma. Obstet Gynecol 55:363.
Liao BS, Twiggs LB, Leung BS, Potish RA, Prem KA, Yu WY. Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. Obstet Gynecol (in press).
Horwitz KB, McGuire WL, Pearson OH, Segaloff A. 1975. Predicting response to endocrine therapy in human breast cancer: A Hypothesis. Science 189:726.
Degenshein GA, Bloom N, Tobin E. 1980. The value of progesterone receptor assays in the management of advanced breast cancer. Cancer 46:2789.
Kiang DT, Frenning DH, Goldman AI, Ascensao VF, Kennedy BJ. 1978. Estrogen receptors and responses to chemotherapy and hormonal therapy in advanced breast cancer. N Engl J Med 299:1330.
Ehrlich CF, Young PCM, Cleary RE. 1981. Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic and carcinomatous endometria: Therapeutic implications. Am J Obstet Gynecol 141:539.
Sanborn BM, Held B, Kuo HS. 1976. Hormonal action in human cervix. II. Specific progesterone binding proteins in human cervix. J Steroid Biochem 7:665.
Terenius L, Lindell A, Persson BH. 1971. Binding of estradiol-17B to human cancer tissue of the female genital tract. Cancer Res 31:1895.
Hahnel R, Martin JD, Masters AM, Ratajczak T, Twada. waddle E. 1979. Estrogen receptors and blood hormone levels in cervical carcinoma and other gynecological tumors. Gynecol Oncol 8:226.
Gao YL, Twiggs LB, Leung BS, Yu WCY, Potish RA, Okagaki T, Adcock LL, Prem KA. 1983. Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma: Clinical and histopathologic correlates. Am J Obstet Gynecol 146:299.
Leung BS, Fletcher WS, Lindell TS, Wood DC, Krippaehne WW. 1973. Predictability of response to endocrine ablation in advanced breast carcinoma: A correlation to estrogen receptor and steroid sulfurylation, Arch Surg 106:515.
Yu WCY, Leung BS, Gao YL. 1981. Effects of estradiol-17B on progesterone receptors and the uptake of thymidine in human breast cancer cell line. CAMA-1, Cancer Res 41:5004.
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1981. Protein measurement with the folin phenol reagent. J Biol Chem 193:265.
Natrajan PK, Muldoon TG, Greenblatt RB, Mahesh VB. 1982. The effects of progestins on estrogen and progesterone receptors in human endometrium. J Reprod Med 27:227.
Potish RA, Twiggs LB, Adcock LL, Prem KA, Savage JE, Leung BS. Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. Cancer (in press).
Lee ET. 1980. Statistical Methods for Survival Data Analysis. Lifetime Learning Publications, Belmont, CA.
Twiggs LB, Potish RA, Adcock LL, Savage JE, Carson LF, Leung BS. Cytosolic estrogen and progesterone receptors as prognostic parameters in stage IB cervical carcinoma. Gynecol Oncol (in press).
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© 1987 Martinus Nijhoff Publishers, Boston
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Twiggs, L.B., Potish, R.A., Leung, B.S. (1987). Cytosolic estrogen and progesterone receptors in primary cervical carcinoma. In: Surwit, E.A., Alberts, D.S. (eds) Cervix Cancer. Cancer Treatment and Research, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2027-2_3
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DOI: https://doi.org/10.1007/978-1-4613-2027-2_3
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