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A Trial of ICRF-187 to Selectively Protect Against Chronic Adriamycin Cardiac Toxicity: Rationale and Preliminary Results of a Clinical Trial

  • J. L. Speyer
  • M. D. Green
  • C. Ward
  • J. Sanger
  • E. Kramer
  • M. Rey
  • J. C. Wernz
  • R. H. Blum
  • M. Meyers
  • F. M. Muggia
  • V. Ferrans
  • P. Stecy
  • F. Feit
  • N. Dubin
  • A. Jacquotte
  • S. Taubes
  • C. London
Part of the Developments in Oncology book series (DION, volume 53)

Abstract

The wide spectrum of anthracycline activity as well as the unique cumulative dose related cardiac toxicity pose a significant clinical challenge. These drugs, particularly doxorubicin (AdriamycinR), constitute some of the most active compounds available to the clinical oncologist. They have activity in both hematologic malignancies and solid tumors. Numerous efforts to improve upon their activity through analogue development or a better dose schedule of administration have not substantially altered the antitumor activity. Further efforts in this area may yet bear fruit. However, at the present time the challenge to improve the therapeutic ratio must be met by reducing toxicity, particularly cardiac toxicity.

Keywords

Leave Ventricular Ejection Fraction Cardiac Toxicity Endomyocardial Biopsy Alpha Tocopherol Baseline Leave Ventricular Ejection Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Von Hoff, D.D., Layard, M.W., Basa, P., et al. (1979) Ann. Intern. Med. 91: 710–717.Google Scholar
  2. 2.
    Benjamin, R.S., Chawla, S.P., Ewer, M.S., Hortobagyi, G.N., Mackay, B., Legha, S.S., Carrasco, C.H., Wallace, S. (1987) Proc. Organ Directed Toxicities of Anticancer Drugs, First International Symposium. Burlington, VT, June 4–6, p. 9.Google Scholar
  3. 3.
    Legha, S.S., Benjamin, R.S., Mackay, B., et al. (1982) Ann. Intern. Med. 96: 133–139.PubMedGoogle Scholar
  4. 4.
    Myers, C.E., Muire, W.P., Liss, R.H., et al. (1977) Science. 197: 165–167.PubMedCrossRefGoogle Scholar
  5. 5.
    Myers, C.E. (1987) Proc. Organ Directed Toxicities of Anticancer Drugs, First International Symposium. Burlington, VT, June 4–6, p. 5.Google Scholar
  6. 6.
    Doroshow, J.H. (1987) Proc. Organ Directed Toxicities of Anticancer Drugs, First International Symposium. Burlington, VT, June 4–6, p. 7.Google Scholar
  7. 7.
    Herman, E.H., Mhatre, R.M., Lee, I.P., and Waravdekar, V.S. (1972) Proc. Soc. Exp. Biol. Med. 140: 234–239.PubMedGoogle Scholar
  8. 8.
    Ferrans, V.J., Herman, E.H., and Hamlin, R.L. (1987) Proc. Organ Directed Toxicities of Anticancer Drugs, First International Symposium. Burlington, VT, June 4–6, p. 11.Google Scholar
  9. 9.
    Herman, E., Mhatre, R, and Chadwick, D. (1974) Toxicol. Appl. Pharmacol. 27: 517–527.PubMedCrossRefGoogle Scholar
  10. 10.
    Herman, E.H., Ferrans, V.J. (1981) Cancer Res. 41: 3436–3440.PubMedGoogle Scholar
  11. 11.
    Von Hoff, D.D., Howser, D., Lewis, B.J., et al. (1981) Cancer Treat Rep. 65: 249–252.Google Scholar
  12. 12.
    Filppi, J.A., Imondi, A.R., Wolgemuth, R.L. (1987) Proc. Organ Directed Toxicities of Anticancer Drugs, First International Symposium. Burlington, VT, June 4–6, p. 22.Google Scholar
  13. 13.
    Speyer, J.L., Green, M.D., Dubin, N., Blum, R.H., Wernz, J.C., Roses, D., Sanger, J., and Muggia, F.M. (1985) Am. J. Med. 78: 555–563.PubMedCrossRefGoogle Scholar
  14. 14.
    Bristow, M.R., Mason, J.W., Billingham, M.E., Daniels, J.R. (1981) Amer. Heart J. 102: 709–718.PubMedCrossRefGoogle Scholar
  15. 15.
    Green, M.D., Speyer, J.L., Stecy, P., Rey, M., Kramer, E., Sanger, J., Feit, F., Blum, R.H., Wernz, J.C., Ward, C., London, C., Dubin, N., Muggia, F.M. (1987) Proc. Am. Soc. Clin. One. 104, p. 28.Google Scholar
  16. 16.
    Doroshow, J.H. (1986) Biochem. Biophys. Res. Commun. 135: 330–335.PubMedCrossRefGoogle Scholar
  17. 17.
    Doroshow, J.H. (1986) Proc. Natl. Acad. Sci. (USA). 83: 4514–4518.CrossRefGoogle Scholar
  18. 18.
    Sinha, B., Katki, A., Batist, G., Cowan, K., and Myers, C. (In Press) Biochemistry.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • J. L. Speyer
  • M. D. Green
  • C. Ward
  • J. Sanger
  • E. Kramer
  • M. Rey
  • J. C. Wernz
  • R. H. Blum
  • M. Meyers
  • F. M. Muggia
  • V. Ferrans
  • P. Stecy
  • F. Feit
  • N. Dubin
  • A. Jacquotte
  • S. Taubes
  • C. London

There are no affiliations available

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