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Cisplatin Nephrotoxicity: New Insights Into Mechanism

  • Chapter
Organ Directed Toxicities of Anticancer Drugs

Part of the book series: Developments in Oncology ((DION,volume 53))

Abstract

Cis-dichlorodiammine platinum (II), or cisplatin, has emerged as a principal chemotherapeutic agent in the treatment of otherwise resistant solid tumors and is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy, however, is its nephrotoxicity, which has made it necessary both to lower its dosage and actively hydrate patients to reduce it. These techniques have proven to be only partially successful as renal failure occurs even at such low doses and especially after its repeated administration (1,2). Use of other means to protect the kidney (3–5) are only partially successful and of uncertain clinical application. It may not be possible to alter or prevent the renal toxicity of cisplatin, however, until a more basic understanding of that toxicity is obtained. This paper summarizes what is known about the biochemical and physiologic aspects of cisplatin nephrotoxicity and gives the results of some recent experiments into its possible mechanism.

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Authors
  1. R. Safirstein
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  2. A. Z. Zelent
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  3. R. Gordon
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Editor information

Editors and Affiliations

  1. Vermont Regional Cancer Center, Burlington, Vermont, USA

    Miles P. Hacker

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    John S. Lazo

  3. Vermont Regional Cancer Center, Burlington, Vermont, USA

    Thomas R. Tritton

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© 1988 Martinus Nijhoff Publishing, Boston

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Safirstein, R., Zelent, A.Z., Gordon, R. (1988). Cisplatin Nephrotoxicity: New Insights Into Mechanism. In: Hacker, M.P., Lazo, J.S., Tritton, T.R. (eds) Organ Directed Toxicities of Anticancer Drugs. Developments in Oncology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2023-4_17

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  • DOI: https://doi.org/10.1007/978-1-4613-2023-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9205-0

  • Online ISBN: 978-1-4613-2023-4

  • eBook Packages: Springer Book Archive

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