Cisplatin Nephrotoxicity: New Insights Into Mechanism

  • R. Safirstein
  • A. Z. Zelent
  • R. Gordon
Part of the Developments in Oncology book series (DION, volume 53)


Cis-dichlorodiammine platinum (II), or cisplatin, has emerged as a principal chemotherapeutic agent in the treatment of otherwise resistant solid tumors and is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy, however, is its nephrotoxicity, which has made it necessary both to lower its dosage and actively hydrate patients to reduce it. These techniques have proven to be only partially successful as renal failure occurs even at such low doses and especially after its repeated administration (1,2). Use of other means to protect the kidney (3–5) are only partially successful and of uncertain clinical application. It may not be possible to alter or prevent the renal toxicity of cisplatin, however, until a more basic understanding of that toxicity is obtained. This paper summarizes what is known about the biochemical and physiologic aspects of cisplatin nephrotoxicity and gives the results of some recent experiments into its possible mechanism.


Outer Medulla Outer Cortex Outer Stripe Renal Fluid Electrolyte Pyrazinoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • R. Safirstein
  • A. Z. Zelent
  • R. Gordon

There are no affiliations available

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