Abstract
Bleomycin, a glycopeptide antineoplastic agent, is used to treat several types of malignancies including squamous cell carcinoma of the head and neck, lymphomas and testicular carcinomas (1). Although the mechanism of action of bleomycin is not fully understood, this chemotherapeutic agent does cause DNA damage (2–4) and inhibits DNA synthesis (5, 6). Interaction of bleomycin with purified DNA results in single and double stranded DNA breaks in addition to releasing free bases (2, 7–9). There is also preferential sensitivity of actively transcribing genes in active chromatin to bleomycin (10).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hussar, D.A. Am. J. Pharm. 146: 37–58, 1974.
Müller, W.E.G., Yamazaki, Z., Breter, H.J. and Zahn, R.K. Eur. J. Biochem. 31: 518–525, 1972.
Sausville, E.A., Peisach, J. and Horwitz, S.B. Biochemistry 17: 2740–2746, 1978.
Sausville, E.A., Stein, R.W., Peisach, J. and Horwitz, S.B. Biochemistry 17: 2746–2754, 1978.
Suzuki, H., Nagai, K., Yamaki, H., Tanaka, N. and Umezawa, H. J. Antibiot. 21: 379–386, 1968.
Muller, W.E.G., Totsuka, A., Nusser, I., Zahn, R.K. and Umezawa, H. Biochem. Pharmacol. 24: 911–915, 1975.
Takeshita, M., Horwitz, S.B. and Grollman, A.P. Virology 60: 455–465, 1974.
Kuo, M.T. and Haidle, C.W. Biochem. Biophys. Acta 335: 109–114, 1974.
Haidle, C.W. and Lloyd, R.S. In: Bleomycin: Current Status and New Development Eds. S. K. Carter, S. T. Crooke and H. Umezawa), Academic Press, New York, N. Y., 1978, p. 21.
Kuo, M.T. Cancer Res. 41: 2439–2443, 1981.
Adamson, I.Y.R. Environ. Health Perspect. 16: 119–126, 1976.
Bedrossian, C.W.M., Greenberg, S.D., Yawn, D.H. and O’Neal, R.M. Arch. Pathol. and Lab. Med. 101: 248–254, 1977.
Snider, G.L., Hayes, J.A. and Korthy, A.L. Am. Rev. Resp. Dis. 117: 1099–1108, 1978.
Giri, S.N., Schwartz, L.W., Hollinger, M.A., Freywald, M.E., Schiedt, M.J. and Zuckerman, J.E. Exptl. and Mol. Pathol. 33 1–14, 1980.
Lazo, J.S. and Humphreys, C.J. Proc. Natl. Acad. Sci. 80: 3064–3068, 1983.
McCullough, B., Collins, J.F., Johanson W.G. and Grover, F.L. J. Clin. Invest. 61: 79–88, 1978.
Sikic, B.I., Young, D.M., Mimmaugh, E.G. and Gram, T.E. Cancer Res. 38: 787–792, 1978.
Stareher, B.C., Kuhn, C. and Overton, J.E. Amer. Rev. Resp. Dis. 117: 299–305, 1978.
Goldstein, R.H., Lucey, E.C., Franzblau, C. and Snider, G.L. Amer. Rev. Resp. Dis. 120: 67–73, 1979.
Sterling, K.M., Detrillo, T., Cutroneo, K.R. and Prestayko, A. Cancer Res. 42: 405–408, 1982.
Zapol, W.M., Trelstad, R.L., Coffey, J.W., Tsai, I. and Salvador, R.A. Am. Rev. Resp. Dis. 119: 547–554, 1979.
Clark, J.G., Overton, J.E., Marino, B.A., Uitto, J. and Starcher, B.C. J. Lab. Clin. Med. 96: 943–953, 1980.
Phan, S.H., Thrall, R.S. and Ward, P.A. Am. Rev. Resp. Dis. 121: 501–506, 1980.
Zuckerman, J.E., Hollinger, M.A. and Giri, S.N. J. Pharmacol. Exptl. Therapeu. 213: 425–431 (1980).
Laurent, G. and Mnulty, R.J. Am. Rev. Respir. Dis. 128: 82–88, 1983.
Cantor, J. O., Cerreta, J.M., Osman, M., Mott, S.H., Mandl, I. and Turino, G.M. Proc. Soc. Exptl. Biol. and Med. 174: 172–181, 1983.
Counts, D.F., Evans, J.N., Detrillo, T.A., Sterling, K.M. and Kelley, J. J. Pharmacol, and Exptl. Therapeu. 219: 675–678, 1981.
Sterling, K.M., Detrillo, T.A., Kotch J.P. and Cutroneo, K.R. Cancer Res. 42: 3502–3506, 1982.
Clark, J.G., Starcher, B.C. and Uitto, J. Biochem. Biophys. Acta 631: 359–370, 1980.
Clark, J.G., Kostal, K.M. and Marino, B.A. J. Clin. Invest. 72: 2082–2091, 1983.
Bitterman, P.B., Adelberg, S. and Crystal, R.G. J. Clin. Invest. 72: 1801–1813, 1983.
Kovacs, E.J. and Kelley, J. J. Leuk. Biol. 37: 1–14, 1985.
Kovacs E.J. and Kelley, J. Am. Rev. Respir. Dis. 133: 68–72, 1986.
Kovacs, E.J. and Kelley, J. Am. J. Pathol. 121: 261–268, 1985.
Clark, J.G., Kostal, K.M. and Marino, B.A, J. Biol. Chem. 257: 8098–8105, 1982.
Sterling, K.M., Harris, M.J., Mitchell, J.J. and Cutroneo, K.R. J. Biol. Chem. 258: 14438–14444, 1983.
Bandman, E. and Gurney, T. Jr. Exptl. Cell Res. 90: 159–168, 1975.
Rudland, P.S., Weil, S. and Hunter, A.R., J. Mol. Biol. 96: 745–766, 1975.
Davies, E., Dumont, J.E. and Vassart, G. Biochem. J. 172: 227–231, 1978.
Cutroneo, K.R., Sterling, K.M. and Shull, S. In: Biology of Extracellular Matrix (Ed. R. P. Mecham), Academic Press, New York, N.Y., 1986, pp. 119–176.
Cockayne, D., Sterling, K.M. Jr., Shull, S., Mintz, K.P., Illeyne S. and Cutroneo, K.R. Biochem. 25: 3202–3209, 1986.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Cutroneo, K.R., Cockayne, D., Sterling, K.M. (1988). Biochemical and Molecular Bases of Bleomycin-Induced Pulmonary Fibrosis: Glucocorticoid Intervention. In: Hacker, M.P., Lazo, J.S., Tritton, T.R. (eds) Organ Directed Toxicities of Anticancer Drugs. Developments in Oncology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2023-4_14
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2023-4_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9205-0
Online ISBN: 978-1-4613-2023-4
eBook Packages: Springer Book Archive