Skip to main content

Pulmonary Toxicity of Anticancer Drugs: Alterations in Endothelial Cell Function

  • Chapter
Organ Directed Toxicities of Anticancer Drugs

Part of the book series: Developments in Oncology ((DION,volume 53))

Abstract

Pulmonary toxicity is a prominent side effect of many anticancer drugs. Although the marrow-sparing antibiotic bleomycin has been identified as the antineoplastic agent with the most serious, life threatening and dose limiting pulmonary toxicity, a number of other drugs have also been reported to produce lung injury; these include carmustine, chlorambucil, cyclophosphamide, cytarabine HCl, estramustine, lomustine, melphalan, methotrexate, mitomycin, procarbazine and semustine1. Ionizing radiation, a common adjunct to cancer chemotherapy, is also a powerful pulmonary toxin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. The Medical Letter 29:29–36 (1987).

    Google Scholar 

  2. Adamson, IYR and Bowden, DH. (1974) Amer. J. Pathol. 77:185–198.

    CAS  Google Scholar 

  3. Aso, Y., Yoneda, K. and Kikkawa, Y. (1976) Lab Invest. 35:558.

    PubMed  CAS  Google Scholar 

  4. Adamson, IYR and Bowden, DH. (1979) Amer. J. Pathol. 96:531–538.

    CAS  Google Scholar 

  5. Nicolson, GL and Custead, SE. (1985) Cane. Res. 45:331–336.

    CAS  Google Scholar 

  6. Tom, WM and Montgomery, MR. (1980) Toxicol. Appl. Pharmacol. 53:64–74.

    Article  PubMed  CAS  Google Scholar 

  7. Newman, RA, Kimberly, PJ, Stweart, JA and Kelley, J. (1980) Cane. Res. 40:3621–3626.

    CAS  Google Scholar 

  8. Catravas, JD, Watkins, CA and Newman, RA. (1987) Amer. Rev. Resp. Dis. 135:A257.

    Google Scholar 

  9. Lazo, JS, Catravas, JD and Gillis, CN. (1981) Biochem. Pharmacol. 30:2577–2584.

    Article  PubMed  CAS  Google Scholar 

  10. Lazo, JS, Catravas, JD, Dobuler, KJ and Gillis, CN. (1983) Toxicol. Appl. Pharmacol. 69:276–282.

    Article  PubMed  CAS  Google Scholar 

  11. Catravas, JD, Lazo, JS, Dobuler, KD, Mills, LR and Gillis, CN. (1983) Amer. Rev. Resp. Dis. 128:740–746.

    PubMed  CAS  Google Scholar 

  12. Lazo, JS. (1981) Toxicol. Appl. Pharmacol. 59:395–404.

    Article  PubMed  CAS  Google Scholar 

  13. Sorensen, PG, Romer, FK and Cortes, S. (1984) Eur. J. Cane. Clin. Oncol. 20:1405–1408.

    Article  CAS  Google Scholar 

  14. Newman, RA, Hacker, MP, Kimberly, PJ and Braddock, JM. (1981) Toxicol. Appl. Pharmacol. 61:469–474.

    Article  PubMed  CAS  Google Scholar 

  15. Catravas, JD, Lazo, JS and Gillis, CN. (1981) J. Pharmacol Exp. Ther. 217:524–529.

    PubMed  CAS  Google Scholar 

  16. Chandler, DB and Giri, SN. (1983) Amer. Rev. Resp. Dis. 128:71–76.

    PubMed  CAS  Google Scholar 

  17. Catravas, JD. (1986) Adv. Exp. Med. 198:445–451.

    Google Scholar 

  18. Catravas, JD and Burch, SE. (1987) Toxicol Appl. Pharmacol.

    Google Scholar 

  19. Lazo, JS, Lynch, TJ and McCallister, J. (1983) Amer. Rev. Resp. Dis. 134:73–78.

    Google Scholar 

  20. Lazo, JS. (1986) Biochem. Pharmacol. 35:1919–1923.

    Article  PubMed  CAS  Google Scholar 

  21. Adamson, IYR and Bowden, DA. (1983) Amer. J. Pathol. 112:274.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Catravas, J.D. (1988). Pulmonary Toxicity of Anticancer Drugs: Alterations in Endothelial Cell Function. In: Hacker, M.P., Lazo, J.S., Tritton, T.R. (eds) Organ Directed Toxicities of Anticancer Drugs. Developments in Oncology, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2023-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2023-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9205-0

  • Online ISBN: 978-1-4613-2023-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics