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The cDna and a Structural Gene for Rat Liver Cytochrome C Oxidase Subunit VIc

  • Guntram Suske
  • Christel Enders
  • Thomas Mengel
  • Bernhard Kadenbach

Abstract

In mammalian tissues cytochrome c oxidase is composed of thirteen different subunits (Kadenbach and Merle, 1981; Kadenbach et al., 1983; Mariottini et al., 1986). The three largest subunits, which are responsible for the catalytic functions, are products of the mitochondrial genome (Anderson et al., 1981; Anderson et al., 1982), whereas the ten smaller subunits are encoded by nuclear DNA and synthesized in the cytosol (Kadenbach and Merle, 1981; Wikström et al., 1981). The functions of these small subunits still remain unknown, although regulatory functions were proposed (Kadenbach and Merle, 1981; Kadenbach, 1986). For yeast it was shown, that subunits IV and Vila (yeast nomenclature) are essential for proper assembly of the holoenzyme (Dowhan et al., 1985; Wright et al., 1986).

Keywords

Bovine Heart Partial Nucleotide Sequence Recombinant Phage Nontranslated Region Cleavable Signal Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Guntram Suske
    • 1
  • Christel Enders
    • 1
  • Thomas Mengel
    • 1
  • Bernhard Kadenbach
    • 1
  1. 1.BiochemieFB der Philipps-UniversitätMarburgDeutschland

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