Abstract
Nuclear-encoded proteins which are destined for import into mitochondria face at least two major problems during the course of transport from their site of synthesis in the cytoplasm to their site of function in the mitochondria. First, they must be sorted specifically to the mitochondrial outer membrane and must avoid being targeted to any of the other cytosol-exposed membranes. Second, they must somehow overcome the hydrophobic barrier of the mitochondrial membranes and pass one or both of the organelle’s lipid bilayers. A molecular understanding of the mechanism of these processes is the ultimate goal of current research on this topic. This paper will present ideas about how the presequence portion of a mitochondrial precursor protein may function both in the sorting and translocation stages of import.
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© 1987 Plenum Press, New York
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Roise, D. (1987). Import of Proteins into Mitochondria: Structural and Functional Role of the Prepeptide. In: Papa, S., Chance, B., Ernster, L. (eds) Cytochrome Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1941-2_28
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DOI: https://doi.org/10.1007/978-1-4613-1941-2_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9078-0
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