Microvasculatory Evaluation of Vasospastic Syndromes
Application of a local cold exposure test to the finger nailfold capillaries reveals the functional difference between normal subjects and patients with Raynaud’s syndrome at the level of the microcirculation. We developed a new method for local cold exposure which uses rapidly decompressed carbondioxide and requires considerably less effort experimentally than previously described systems (1). The effect of cold exposure on nailfold capillary blood flow was studied extensively in normal subjects and in patients with primary and secondary Raynaud’s syndrome by means of television (TV-)microscopy. The cold exposure of the capillaries consistently resulted in a greater reduction of the erythrocyte flow velocity in patients with Raynaud’s syndrome than in patients with normal conditions or other diseases. The flow stop was found to be a reaction specific to vasospastic disease (2–5).
KeywordsIschemia Migraine Nifedipine Thromboxane
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