Microvasculatory Evaluation of Vasospastic Syndromes

  • H. Saner
  • H. Würbel
  • F. Mahler
  • J. Flammer
  • P. Gasser
Part of the Advances in Experimental Medicine and Biology book series (ABBI, volume 7)

Abstract

Application of a local cold exposure test to the finger nailfold capillaries reveals the functional difference between normal subjects and patients with Raynaud’s syndrome at the level of the microcirculation. We developed a new method for local cold exposure which uses rapidly decompressed carbondioxide and requires considerably less effort experimentally than previously described systems (1). The effect of cold exposure on nailfold capillary blood flow was studied extensively in normal subjects and in patients with primary and secondary Raynaud’s syndrome by means of television (TV-)microscopy. The cold exposure of the capillaries consistently resulted in a greater reduction of the erythrocyte flow velocity in patients with Raynaud’s syndrome than in patients with normal conditions or other diseases. The flow stop was found to be a reaction specific to vasospastic disease (2–5).

Keywords

Ischemia Migraine Nifedipine Thromboxane 

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References

  1. 1.
    Mahler F., Saner H., Boss Ch. and Annaheim M. Local cold exposure test for capillaroscopic examination of patients with Raynaud’s syndrome (Microvascular Research, in press).Google Scholar
  2. 2.
    Saner H., Würbel H., Foglia E., Linder M., Mahler F. Lokaler Kälteex-positionstest der Nagelfalzkapillaren bei Patienten mit vasospastischer Angina pectoris. Schweiz.med.Wschr. 1986; 116 (Suppl.20): 72Google Scholar
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    Mahler F., Saner H., Marth D., Ursenbacher B. Local cold exposure test for examination of the nailfold capillary circulation in Raynaud’s syndrome. Inter Angiology 1983; 2 (4): 137–142.Google Scholar
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    Mahler F., Saner H., Annaheim M., Linder H.R. Capillaroscopic examination of erythrocyte flow velocity in patients with Raynaud’syndrome by means of a local cold exposure test. Progr.appl. Microcirc, vol. 11,pp 47–59, Karger, Basel 1986.Google Scholar
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    Gasser P., Flammer J., Guthauser U., Niesel P., Mahler F., Linder H.R. Bedeutung des vasospastischen Syndroms in der Augenheilkunde. Klin. Mbl. Augenheilk. (in press).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. Saner
    • 1
  • H. Würbel
    • 1
  • F. Mahler
    • 1
  • J. Flammer
    • 1
  • P. Gasser
    • 1
  1. 1.Department of Angiology InselspitalUniversity Clinic of MedicineBernSwitzerland

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