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A Simple Method for HbF Analysis

  • Chapter
Continuous Transcutaneous Monitoring

Part of the book series: Advances in Experimental Medicine and Biology ((ABBI,volume 7))

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Abstract

It has been discussed by several authors1–4 that oxygen saturation (SO2) determined by CO-oxymeters are affected by fetal hemoglobin (HbF). This artefact depends on the wavelengths used to collect absorbance data and/ or the extinction coefficients used to calculate the hemoglobin derivatives. Increased HbF and oxyhemoglobin (HbO2) in human blood elevate the carboxyhemoglobin (HbCO) percentage and cause falsely underestimated SO2 values.

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References

  1. A. Zwart, A. Buursma, B. Oeseburg and W. G. Zijlstra, Determination of hemoglobin derivatives with the IL 282 CO-oxymeter as compared with a manual spectrophotometric five-wavelength method, Clin Chem 27:1903 (1981)

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  2. P. J. H. Cornelissen, C .L. M. van Woensel, W. C. van Oel and P. A. de Jong, Correction factors for hemoglobin derivatives in fetal blood as measured with the IL 282 CO-oxymeter, Clin Chem 29:1555 (1983)

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  3. R. Huch, A. Huch, P. Tuchschmid, W. G. Zijlstra and A. Zwart, Carboxyhemoglobin concentration in fetal cord blood, Pediatrics 71:461 (1983)

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  4. M. S. Jennis and J. L. Peabody,Pulse oximetry-an alternative method for the assessement of oxygenation in newborn infants, Pediatrics in press

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  5. P. Tuchschmid, Errors in the measurement of CO-hemoglobin in fetal blood by automated multicomponent analysis: cause and correction, This volume

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Author information

Authors and Affiliations

  1. Perinatal Physiology Unit Department of Obstetrics, University of Zurich, CH-8091, Zurich, Switzerland

    Ursula von Mandach, Peter Tuchschmid, Albert Huch & Renate Huch

Authors
  1. Ursula von Mandach
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  2. Peter Tuchschmid
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  3. Albert Huch
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  4. Renate Huch
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Editor information

Editors and Affiliations

  1. Department of Obstetrics, University Hospital, Zurich, Switzerland

    Albert Huch , Renate Huch  & Gösta Rooth ,  & 

  2. Departement für Frauenheilkunde, Klinik und Poliklinik für Geburtshilfe, Frauenklinikstrasse 10, CH-8091, Zürich, Switzerland

    Albert Huch  & Renate Huch  & 

  3. Oefre Slottsgatan 14 C, S-75235, Uppsala, Sweden

    Gösta Rooth

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© 1987 Plenum Press, New York

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von Mandach, U., Tuchschmid, P., Huch, A., Huch, R. (1987). A Simple Method for HbF Analysis. In: Huch, A., Huch, R., Rooth, G. (eds) Continuous Transcutaneous Monitoring. Advances in Experimental Medicine and Biology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1927-6_36

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  • DOI: https://doi.org/10.1007/978-1-4613-1927-6_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9071-1

  • Online ISBN: 978-1-4613-1927-6

  • eBook Packages: Springer Book Archive

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