Abstract
The diagnosis of diabetic microangiopathy is usually secured by an ophthal-mological examination of the eye fundus. But the vessels which are viewed by funduscopy are small arteries and no terminal vessels. Thus even fun-duscopy is only an indirect method for diagnosing microangiopathy which beyond that gives qualitative information only. For the first time, Ewald et al. (1981) showed that the tcPO2 method can successfully be used for the assessment of microcirculation in diabetic children. But the vascular changes of diabetic adults are much more difficult to evaluate by this technique because of two reasons, i. e., thickening of the horny layer and overlapping of microvascular and macrovascular disturbances. In the present work, special stimulation tests have been used in order to improve the applicability of the tcPO2 technique. The investigations aimed for developing a method of examination which is suitable for a quantitative assessment of microangiopathy in adult diabetic patients.
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References
Alexander, K., Teusen, R., and Mitzkat, H. J., 1968, Vergleichende Messungen der Extremitätendurchblutung bei Diabetikern und Stoffwechselgesunden, Klin. Wschr. 46: 234
Andersson, R. G. G., Aberg, G., Brattsand, R., Ericsson, E., and Lundholm,L., 1977, Studies on the mechanism of flush induced by nicotinic acid, Acta Pharmacol. et toxicol., 41: 1
Crossland, J., 1970, Lewis’s Pharmacology,Livingstone, Edingburgh, London (1970)
Ewald, U., Tuvemo, T., and Rooth, G., 1981, Early reduction of vascular reactivity in diabetic children detected by transcutaneous oxygen electrode, Lancet: 1287
Furchgott, R. F., and Zawadzki, J. V., 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, 288: 373
Huch, R., Huch, A., and Lubbers, D. W., 1981, Transcutaneous PO2, Thieme-Stratton Inc., Stuttgart, New York
Railton, R., Newman, P., Hislop, J., and Harrower, A. D. B., 1983, Reduced transcutaneous oxygen tension and impaired vascular response in type I, (insulin-dependent) diabetes, diabetologia, 25: 340
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© 1987 Plenum Press, New York
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Weindorf, N., Schultz-Ehrenburg, U., Altmeyer, P. (1987). Diagnostic Assessment of Diabetic Microangiopathy by TCPO2 Stimulation Tests. In: Huch, A., Huch, R., Rooth, G. (eds) Continuous Transcutaneous Monitoring. Advances in Experimental Medicine and Biology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1927-6_15
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DOI: https://doi.org/10.1007/978-1-4613-1927-6_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9071-1
Online ISBN: 978-1-4613-1927-6
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