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Development and Recognition of the Transformed Cell pp 111–121Cite as

The Receptor for Epidermal Growth Factor

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Abstract

Epidermal growth factor (EGF) is a well-characterized growth factor that was initially isolated from mouse submaxillary glands.(1–3) The low-molecular-weight growth factor (M r 6000) can be isolated as a component of a high-molecular-weight complex with an associated arginine esterase activity. (4,5) EGF has been found in all mammals and, in humans, is a component of nearly all body fluids.(6,7) A variety of biological responses are mediated by EGF in vivo and in vitro, in a diverse number of cells including epidermal and epithelial cells, which are particularly responsive in the intact animal.(7) It is important to note that almost 90% of all malignancies are derived from epithelial cells.

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  1. Departments of Medicine and Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    Wendelyn H. Inman & Graham Carpenter

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  1. Wendelyn H. Inman
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  1. Division of Immunology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104-6082, USA

    Mark I. Greene

  2. Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka, 553, Japan

    Toshiyuki Hamaoka

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© 1987 Plenum Press, New York

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Inman, W.H., Carpenter, G. (1987). The Receptor for Epidermal Growth Factor. In: Greene, M.I., Hamaoka, T. (eds) Development and Recognition of the Transformed Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1925-2_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1925-2_8

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