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Two erbB-Related Protooncogenes Encoding Growth Factor Receptors

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Book cover Development and Recognition of the Transformed Cell

Abstract

Oncogenes were first found in the genome of RNA tumor viruses and termed viral oncogenes. To date, as many as 20 viral oncogenes have been identified.(1) All these genes originated from genes carried by host cells, which were tentatively named cellular oncogenes or protooncogenes.(2) The remarkable conservation of protooncogenes over vast distances of evolutionary time(3) had led to the idea that protooncogenes play key roles in vital functions in organisms. This became apparent with the discovery that the v-sis gene product of simian sarcoma virus showed extensive identity with platelet-derived growth factor (PDGF)(4,5) and that the v-erbB gene of avian erythroblastosis virus was derived from the epidermal growth factor (EGF) receptor gene.(6–8) These findings, followed by reports of close relationships between growth-controlling proteins and oncogene products, shed light on oncogene expression and the outgrowth of tumor cells. Certain oncogenes are expressed in differentiated cells(9–11) and their protein products may be important in cellular functions that are not directly related to cell growth.

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  1. Institute of Medical Science, University of Tokyo, Tokyo 108, Japan

    Tadashi Yamamoto & Kumao Toyoshima

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  1. Tadashi Yamamoto
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  2. Kumao Toyoshima
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  1. Division of Immunology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104-6082, USA

    Mark I. Greene

  2. Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka, 553, Japan

    Toshiyuki Hamaoka

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© 1987 Plenum Press, New York

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Yamamoto, T., Toyoshima, K. (1987). Two erbB-Related Protooncogenes Encoding Growth Factor Receptors. In: Greene, M.I., Hamaoka, T. (eds) Development and Recognition of the Transformed Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1925-2_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1925-2_7

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