Relationship of the c-fms Protooncogene Product to the CSF-1 Receptor

  • Charles J. Sherr


The genomes of RNA tumor viruses contain viral oncogene sequences derived by recombination from protooncogenes present in all normal cells.(1) As the biochemical functions of protooncogene products are elucidated, we are beginning to formulate a better understanding of the processes that govern cell proliferation and are gaining parallel insights into how aberrant stimuli for growth predispose to malignancy. The products of at least two classes of retroviral oncogenes, including those encoding tyrosine-specific kinases (e.g., v-src, v-abl, v-fes) and guanine nucleotide-binding proteins (the v-ras genes), exert their transforming functions at the plasma membrane. These products are thought to act by emulating the functions of cell surface proteins that transduce extracellular hormonal signals. The fact that two members of the tyrosine kinase gene family (v-erbB and v-fms) encode aberrant forms of cell surface receptors for polypeptide growth factors(2,3) has underscored the possibility that critical alterations in receptor function might directly contribute to neoplasia.


Mononuclear Phagocyte Histiocytic Sarcoma Polypeptide Growth Factor Feline Leukemia Virus Human Choriocarcinoma Cell Line 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Charles J. Sherr
    • 1
  1. 1.Department of Tumor Cell BiologySt. Jude Children’s Research HospitalMemphisUSA

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