Abstract
The past decade has seen major advances in our understanding of the molecular events involved in malignant transformation. Studies of RNA tumor viruses initially identified specific genes that were able to confer neoplastic properties on cells in tissue culture and that were responsible for tumor formation in vivo.(1) These genes were termed oncogenes. Subsequently, it was shown that genes closely related to retroviral oncogenes (protooncogenes) exist in the genomes of all eukaryotic cells. These protooncogenes have been highly conserved in evolution and are likely to play important roles in normal growth and development.(1,2) It is now clear that retroviruses have acquired their oncogenes by retroviral transduction of cellular protooncogenes. It is thought that elevated expression and/or structural alterations of protooncogenes within the retroviral genome are responsible for the abilities of some retroviruses to cause neoplastic transformation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bishop, J. M., and Varmus, H. E., 1982, Function and origin of retroviral transforming genes, in: RNA Tumor Viruses. (R. Weiss, N. Teich, H. Varmus, and J. Coffin, eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., pp. 999–1109.
Bishop, J. M., 1983, Cellular oncogenes and retroviruses, Annu. Rev. Biochem. 52:301–354.
Weinberg, R. A., 1985, The action of oncogenes in the cytoplasm and the nucleus, Science 230:770–775.
Cooper, G. M., 1982, Cellular transforming genes, Science 217:801–806.
Land, H., Parada, L. F., and Weinberg, R. A., 1983, Cellular oncogenes and multistep carcinogenesis, Science 222:771–778.
Santos, E., Martin-Zanca, D., Reddy, E. P., Pierotti, M. A., Porta, G. D., and Barbacid, M., 1984, Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient, Science 223:661–664.
Feig, L. A., Bast, R. C., Knapp, R. C., and Cooper, G. M., 1984, Somatic activation of rask gene in a human ovarian carcinoma, Science 223:698–700.
Taub, R., Kirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick, S., Aaronson, S., and Leder, P., 1982, Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells, Proc. Natl. Acad. Sci. USA 79:7837–7841.
de Klein, A., van Kessel, A. G., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., and Stephenson, J. R., 1982, A cellular oncogene is translocated to the Philadelphia chromosome in the chronic myelogenous leukemia, Nature 300:765–767.
Xu, Y., Richert, N. Ito, S., Merlino, G. T., and Pastan, I., 1984, Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines, Proc. Natl. Acad. Sci. USA 81:7308–7312.
Hendler, F. J., and Ozanne, B. W., 1984, Human squamous cell lung cancers express increased epidermal growth factor receptors, J. Clin. Invest. 74:647–651.
Hunter, T. J., 1984, Oncogenes and proto-oncogenes: How do they differ? J. Natl. Cancer Inst. 73:773–786.
Shih, C., Padhy, L. C., Murray, M., and Weinberg, R. A., 1981, Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts, Nature 290:261–264.
Schecter, A. L., Stern, D. F., Vaidyanathan, L., Decker, S. J., Drebin, J. A., Greene, M. I., and Weinberg, R. A., 1984, The neu oncogene: An erbB related gene encoding a 185,000-Mr tumor antigen, Nature 312:513–516.
Coussens, L., Yang-Feng, T. L., Liao, Y., Chen, E., Gray, A., McGrath, J., Seeburg, P. H., Libermann, T. A., Schlessinger, J., Franke, U., Levinson, A., and Ullrich, A., 1985, Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene, Science 230:1132–1139.
Yamamoto, T., Ikawa, S., Akiyama, T., Semba, K., Nomura, N., Miyajima, N., Saito, T., and Toyoshima, K., 1986, Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor, Nature 319:230–234.
Akiyama, T., Sudo, C., Ogawara, H., Toyoshima, K., and Yamamoto, T., 1986, The product of the human c-erbB-2 gene: A 185-kilodalton glycoprotein with tyrosine kinase activity, Science 232:1644–1646.
Bargmann, C., Hung, M. C., and Weinberg, R. A., 1986, Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185, Cell 45:649–657.
Drebin, J. A., Link, V. C., Stern, D. F., Weinberg, R. A., and Greene, M. I., 1984, Immune responses against transforming gene associated antigens, in: Regulation of the Immune System (E. Sercarz, H. Cantor, and L. Chess, eds.), Liss, New York, pp. 919–928.
Drebin, J. A., Stern, D. F., Link, V. C., Weinberg, R. A., and Greene, M. I., 1984, Monoclonal antibodies identify a cell surface antigen associated with an activated cellular oncogene, Nature 312:545–548.
Schreiner, G. F., and Unanue, E. R., 1977, Capping and the lymphocyte: Models for membrane reorganization, J. Immunol. 119:1549–1551.
Baumann, H., and Doyle, D., 1980, Metabolic fate of cell surface glycoproteins during immunoglobulin-induced internalization, Cell 21:897–907.
Boyse, E. A., Stocken, E., and Old, L. J., 1967, Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody, Proc. Natl. Acad. Sci. USA 58:954–959.
Drebin, J. A., Link, V. C., Stern, D. F., Weinberg, R. A., and Green, M. I., 1985, Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies, Cell 41:695–706.
Pollack, R., Chen, S., Powers, S., and Verderame, M., 1984, Transformation mechanisms at the cellular level, in: Advances in Viral Oncology ,Vol. 3 (G. Klein, ed.), Raven Press, New York, pp. 3–28.
Drebin, J. A., Link, V. C., Weinberg, R. A., and Greene, M. I., 1987, Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen, Proc. Natl. Acad. Sci. USA (in press).
Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., and Waterfield, M. D., 1984, Close similarity of epidermal growth factor receptor and \-erbBoncogene protein sequences, Nature 307:521–527.
Roussel, M. F., Rettenmier, C. W., Look, A. T., and Sherr, C. J., 1984, Cell surface expression of v-/ww-coded glycoproteins is required for transformation, Mol. Cell. Biol. 4:1999–2009.
Yokata, J., Yamamoto, T., Toyoshima, K., Terada, M., Sugimura, T., Battifora, H., and Cline, M. J., 1986 Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo, Lancet 1:765–767.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Drebin, J.A., Link, V.C., Greene, M.I. (1987). Monoclonal Antibodies Reactive with the neu Oncogene Product Inhibit the Neoplastic Properties of neu-Transformed Cells. In: Greene, M.I., Hamaoka, T. (eds) Development and Recognition of the Transformed Cell. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1925-2_5
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1925-2_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9070-4
Online ISBN: 978-1-4613-1925-2
eBook Packages: Springer Book Archive