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Electrotonic Coupling in the Nervous System

  • Chapter
Cell-to-Cell Communication

Abstract

The topic of cell-to-cell communication in the nervous system primarily concerns the electrotonic synapse. This is a low-resistance intercellular pathway that permits the direct flow of electrical current between coupled cells, thus obviating the need for a neurochemically mediated step. The first description of a definitive electrotonic synapse, the crayfish motor giant synapse, appeared in 1957 (Furshpan and Potter, 1957) and numerous other examples from nervous systems of many phyla have since been demonstrated. By definitive we mean a specific synaptic structure mediating neurotransmission, as opposed to a fusion or close apposition of neighboring cells. Several lines of anatomical and pharmacological evidence have shown that this structure is the gap junction intercellular channel (see Section 4).

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  1. Department of Anatomical Sciences, Health Sciences Center, State University of New York, Stony Brook, New York, 11794, USA

    Stewart W. Jaslove & Peter R. Brink

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    Walmor C. De Mello

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Jaslove, S.W., Brink, P.R. (1987). Electrotonic Coupling in the Nervous System. In: De Mello, W.C. (eds) Cell-to-Cell Communication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1917-7_4

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