Cell Membranes pp 365-405 | Cite as

Early Cytoplasmic Signals and Cytoskeletal Responses Initiated by Growth Factors in Cultured Cells

  • Paul L. McNeil
  • D. Lansing Taylor


Growth factors activate quiescent cells in a stimulus-response coupling process that is initiated by binding the growth factor to its receptor on the cell surface (see Carpenter, 1984). The ultimate result of such activation is DNA synthesis and cell division (mitogenesis). However, such activated cells exhibit a host of earlier responses, some of which begin seconds poststimulation. These “early” cellular responses to growth factors include endocytosis, changes in the cytoskeleton, cell motility, phospholipid turnover, Na+/H+ exchanger activation, fluxes of a variety of ions, calcium transients, protein synthesis, changes in cyclic nucleotide levels, phosphorylation of specific proteins, and gene transcription. The connection, if any, of these early cellular responses with the later DNA synthetic response is obscure at present.


Platelet Derive Growth Factor Stress Fiber Cholera Toxin Phorbol Ester Calcium Transient 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Paul L. McNeil
    • 1
  • D. Lansing Taylor
    • 1
  1. 1.Department of Biological Sciences and Center for Fluorescence Research in Biomedical SciencesCarnegie-Mellon UniversityPittsburghUSA

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