Effect of Growth Hormone on Carbohydrate and Lipid Metabolism: An Overview
Approximately 60 years ago, Houssay and his colleagues described hypersensitivity to insulin in hypophysectomized (hypox) animals (1). Further work documented a primary effect of growth hormone (GH) in this phenomenon (1). Over the ensuing years, numerous investigators have sought to define the role of GH in carbohydrate and lipid metabolism. Unfortunately, no unified picture has emerged. Both “insulin-like” and “anti-insulin-like” effects have been documented although the physiological significance of the former is uncertain. Major controversies surround the relationship between structure and function of the GH molecule. Indeed, some believe that most of the reported effects of GH are due to contaminants in the hormone preparation. With two exceptions (2,3), reviews in this area (4–10) have focused mainly on the author–s own work in a circumscribed field, e.g., in vivo effects after GH administration (6,7,9), tissue effects in vitro (5,7), or effects on lipolysis (4,8,10). Furthermore, these reviews were published more than 10 years ago.
KeywordsGrowth Hormone Lipid Metabolism Tissue Effect Pituitary Growth Hormone Growth Hormone Administration
Unable to display preview. Download preview PDF.
- 2.De Bodo RC, Altszuler N. Insulin hypersensitivity and physiological insulin antagonists. Physiol Rev 1958; 38:389.Google Scholar
- 3.Weil R. Pituitary growth hormone and intermediary metabolism. I. The hormonal effect on the metabolism of fat and carbohydrate. Acta Endocrinol (Copenh) 1965; 49(suppl):98.Google Scholar
- 4.Fain JN. Studies on the role of RNA and protein synthesis in the lipolytic action of growth hormone in isolated fat cells. In: Weber G, ed. Adv in enzyme regulation. Oxford: Pergamon Press, 1967.Google Scholar
- 7.Mahler RJ, Szabo 0. A postulated mechanism for the insulin synergistic and insulin antagonistic action of growth hormone. Adv Metab Disord 1970; l(suppl 1):147.Google Scholar
- 9.Altszuler N. Action of growth hormone and carbohydrate metabolism. In: Knobil E, Sawyer WH, eds. Handbook of physiology. Washington, DC: American Physiological Society, 1974.Google Scholar
- 10.Rao AJ, Ramachandran J. Growth hormone and the regulation of lipolysis. In: Li CH, ed. Hormonal proteins and peptides. New York: Academic Press, 1977.Google Scholar