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Acromegaly pp 193-195 | Cite as

Effect of Growth Hormone on Carbohydrate and Lipid Metabolism: An Overview

  • Mayer B. Davidson

Abstract

Approximately 60 years ago, Houssay and his colleagues described hypersensitivity to insulin in hypophysectomized (hypox) animals (1). Further work documented a primary effect of growth hormone (GH) in this phenomenon (1). Over the ensuing years, numerous investigators have sought to define the role of GH in carbohydrate and lipid metabolism. Unfortunately, no unified picture has emerged. Both “insulin-like” and “anti-insulin-like” effects have been documented although the physiological significance of the former is uncertain. Major controversies surround the relationship between structure and function of the GH molecule. Indeed, some believe that most of the reported effects of GH are due to contaminants in the hormone preparation. With two exceptions (2,3), reviews in this area (4–10) have focused mainly on the author–s own work in a circumscribed field, e.g., in vivo effects after GH administration (6,7,9), tissue effects in vitro (5,7), or effects on lipolysis (4,8,10). Furthermore, these reviews were published more than 10 years ago.

Keywords

Growth Hormone Lipid Metabolism Tissue Effect Pituitary Growth Hormone Growth Hormone Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Houssay BA. The hypophysis and metabolism. N Engl J Med 1936; 214:961.CrossRefGoogle Scholar
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    De Bodo RC, Altszuler N. Insulin hypersensitivity and physiological insulin antagonists. Physiol Rev 1958; 38:389.Google Scholar
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Mayer B. Davidson
    • 1
  1. 1.Department of MedicineCedars-Sinai Medical CenterLos AngelesUSA

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