Although striking clinical features of acromegaly had been noticed for a long time, their association with hypersecretion of growth hormone (GH) was first suggested by Cushing. Since then, many attempts have been made to demonstrate an increase of GH in plasma from acromegalic patients. Early studies using the tibia epiphyseal bioassay method revealed the presence of growth-promoting factors in lyophilized plasma from acro-megalic patients (1). It was difficult, however, to quantify plasma GH levels using this bioassay method. The hemoagglutination inhibition assay offered greater sensitivity but this procedure was still not satisfactory for measuring the small amounts of GH present in plasma (2). More recently the sensitive and reliable measurement of plasma GH was made possible by the introduction of a radioimmunoassay (RIA) for GH (3,4). Since then, RIAs for GH have been extensively used for studying GH secretion in patients with acromegaly. In this article, we discuss GH secretion in acromegalic patients based on results obtained from studies conducted in our laboratory as well as findings reported in the literature.
KeywordsGrowth Hormone Vasoactive Intestinal Polypeptide Growth Hormone Secretion Adenoma Cell Acromegalic Patient
Unable to display preview. Download preview PDF.
- 1.Kinsell LW, Michaels GD, Li CH, Larsen WE. Studies in growth. I. Interrelationship between pituitary growth factor and growth-promoting androgens in acromegaly and gigantism. II. Quantitative evaluation of bone and soft tissue growth in acromegaly and gigantism. J Clin Endocrinol 1947; 8:1013.CrossRefGoogle Scholar
- 13.Tolis G, Koutsilieris .M, Bertrand G. Endocrine diagnosis of growth hormone-secreting pituitary tumors. In: Black PM, et al., eds. Secretory tumors of the pituitary gland. New York: Raven Press, 1984.Google Scholar
- 17.Tanaka K, Watanabe T, Yoshida H, Shimizu N. Effect of synthetic ovine corticotropin-releasing factor on growth hormone secretion in patients with acromegaly. Endocrinol Jpn 1984; 31:353.Google Scholar
- 19.Kato Y, Matsushita N, Ohta H, Tojo K, Shimatsu A, Imura H. Regulation of prolactin secretion. In: Imura H, ed. The pituitary gland. New York: Raven Press, 1985.Google Scholar
- 22.Kato Y, Shimatsu A, Matsushita N, et al. Regulation of pituitary hormone secretion by VIP and related peptides. In: Labrie F, Proulx L, eds. Endocrinology. Amsterdam: Elsevier Science Publishers, 1984.Google Scholar
- 29.von Werder K, Muller OA, Hartl R, Losa M, Stalla GK. Growth hormone releasing factor (hpGRF)-stimulation test in normal controls and acromegalic patients. J Endocrinol Invest 1984; 7:185.Google Scholar
- 37.Besser GM, Thorner MO, Wass JAH, et al. Bromocriptine treatment of acromegaly. Q J Med 1976; 45:695.Google Scholar
- 40.Lamberts SWJ, Klijn JGM, van Vroonhoven CCJ, Stefanko SZ, Liuzzi A. The role of prolactin in the inhibitory action of bromocriptine on growth hormone secretion in acromegaly. Acta Endocrinol (Copenh) 1983; 103:446.Google Scholar
- 44.Kato Y, Katakami H, Imura H. Role of neuropeptides in the control of growth hormone secretion in man and rats. In: Shizume K, Takano K, eds. Growth and growth factors. Tokyo: University of Tokyo Press, 1980.Google Scholar
- 45.Lamberts SWJ, Klijn JGM, van Vroonhoven LCJ, Stefanko SZ. Different responses of growth hormone secretion to guanfacine, bromocriptine, and thyrotropin-releasing hormone in acromegalic patients with pure growth hormone (GH)-containing and mixed GH/prolactin-containing pituitary adenomas. J Clin Endocrinol Metab 1985; 60:1148.PubMedCrossRefGoogle Scholar
- 47.Kato Y, Kabayama Y, Ohta H. Effective long-term treatment with cyproheptadine of patients with acromegaly [Abstract]. 65th Annual Meeting of the Endocrine Society, San Antonio, TX, 1983.Google Scholar
- 48.Ishibashi M, Fukushima I, Yamaji T. Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. Acta Endocrinol (Copenh) 1985; 109:474.Google Scholar
- 49.Ishikawa E, Hashida S, Kakogawa K, Ohtaki S. Human growth hormone. In: Bergmeyer HU, ed. Methods of enzymatic analysis. 3rd ed. Weinheim FRG: VCH Verlagsgesellschaft, 1986.Google Scholar