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Nicotine: Abuse Liability, Dependence Potential and Pharmacologic Treatment of Dependence

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Book cover Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

Clinical observations, historical anecdotes, and testimony, suggest that at least some users of tobacco are unable to permanently abstain even when ill health is evident (e.g., Connolly, Winn, Hecht, Henningfield, Hoffman, and Walker, 1986). However, whereas such observations suggest that tobacco self-administration (S-A) can become an addictive behavior, such observations are not scientifically definitive statements that provide the basis for evaluating the abuse liability and dependence potential of tobacco products. Specifically, such observations do not provide a basis for differentiating tobacco S-A from other commonly accepted “addictive behaviors” such as television watching, exercise, or excessive eating; furthermore, such observations do not provide scientifically valid evidence that an addictive drug is critical to the maintenance of the addictive behavior. The distinction between nonspecific addictive behaviors and those involving certain drugs is not just semantic; the implications are critical to issues of public health, legislative jurisdiction, and treatment of the behavior. The purpose of the present report is to summarize evidence that tobacco is a dependence-producing substance according to the same scientific criteria by which other substances are evaluated.

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Author information

Authors and Affiliations

  1. NIDA Addiction Research Center, P.O. Box 5180/4940, Eastern Avenue, Baltimore, MD, 21224, USA

    Jack E. Henningfield, Steven R. Goldberg & Donald R. Jasinski

  2. National Institute on Drug Abuse Addiction Research Center, USA

    Jack E. Henningfield & Steven R. Goldberg

  3. School of Medicine, The Johns Hopkins University, USA

    Jack E. Henningfield & Donald R. Jasinski

  4. School of Medicine, University of Maryland, USA

    Steven R. Goldberg

Authors
  1. Jack E. Henningfield
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  2. Steven R. Goldberg
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  3. Donald R. Jasinski
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Henningfield, J.E., Goldberg, S.R., Jasinski, D.R. (1987). Nicotine: Abuse Liability, Dependence Potential and Pharmacologic Treatment of Dependence. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_6

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

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