Abstract
Nicotinic cholinergic receptors in the mammalian central nervous system have eluded the exquisitely detailed characterization that has been achieved for the nicotinic receptors in the electric organs of fish and in the mammalian neuromuscular junction. Although radioactively labeled alpha-bungarotoxin -which has been instrumental in studies of the electric organ and muscle receptor -binds to sites in mammalian brain, the toxin itself does not appear to affect nicotinic cholinergic receptor mediated neurotransmission in the mammalian CNS, and the binding sites in brain do not appear to have certain characteristics expected of a functional nicotinic cholinergic receptor (Duggan et al., 1976a; 1976b; Carbonetto et al., 1978). The lack of a suitable probe for the CNS nicotinic cholinergic receptor has been a major obstacle to understanding the molecular pharmacology and neurobiology of these receptors, their effector mechanisms, their regulation, and their possible role in physiological and pathophysiological processes.
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© 1987 Plenum Press, New York
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Kellar, K.J., Schwartz, R.D., Martino, A.M. (1987). Nicotinic Cholinergic Receptor Recognition Sites in Brain. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_30
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DOI: https://doi.org/10.1007/978-1-4613-1911-5_30
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