Stereoselectivity of Nicotine’s Central Effects and Its Relationship to Pain and Cardiovascular Function

  • Billy R. Martin
Part of the Advances in Behavioral Biology book series (ABBI, volume 31)


Nicotine produces a wide range of effects on the central nervous system which include convulsions (1), prostration (2), antinociception (3–11), release of antidiuretic hormone (12,13), tremors (13,14), as well as alterations in behavior (15,16), motor performance (3, 10, 17–19), gastric acid secretion (20–22), the cardiovascular system (7,23–30), learning (31), etc. The mechanisms by which nicotine produces these myriad effects have not been fully elucidated. Numerous studies have been carried out in an effort to characterize the effects of nicotine on central neurotransmitter functionality, as reviewed by Aceto and Martin (32) as well as contributors in this volume.


Gastric Acid Secretion Nicotine Receptor Antinociceptive Effect Conditioned Taste Aversion Antinociceptive Activity 
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© Plenum Press, New York 1987

Authors and Affiliations

  • Billy R. Martin
    • 1
  1. 1.Department of Pharmacology and Toxicology Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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