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Central Nicotinic Regulation of Arterial Blood Pressure

  • Chapter
Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

Effects of nicotine on the cardiovascular control of the central nervous system have been studied for many years by numerous investigators (1). Intraventricular or intracisternal administration of nicotine produced an increase or a decrease in blood pressure and heart rate in many animal species including the cat (2–6), dog (7), rat (8,9), and goat (10). Further, some investigators have studied cardiovascular responses to nicotine applied at discrete regions of the brain, including the posterior hypothalamus (11), ventral surface of the medulla oblongata (12–14), and lateral medullary reticular pressor areas (11) of the cat, and the nucleus ambiguus of the dog (15). These central actions of nicotine were abolished by hexamethonium or mecamylamine (4,7–12,15), suggesting the involvement of a central nicotinic cholinergic mechanism in the actions. Recently, nicotinic acetylcholine receptors have been detected on rodent (16–19) and human (20) brain membranes. However, exact central nicotinic mechanisms responsible for cardiovascular responses are not yet fully understood. The purpose of the present study was to localize nicotine-sensitive sites responsible for cardiovascular effects in the dorsal medulla oblongata of the rat. Central or peripheral mechanisms relating to the action of nicotine were also examined. Further, the medullary nicotine action was evaluated also in experimentally hypertensive rats.

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Authors and Affiliations

  1. Department of Pharmacology, Yokohama City University School of Medicine, Urafunecho, Minami-ku, Yokohama 232, Japan

    T. Kubo

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  1. T. Kubo
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Kubo, T. (1987). Central Nicotinic Regulation of Arterial Blood Pressure. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_17

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

  • eBook Packages: Springer Book Archive

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