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Nicotinic Modulation of Dopaminergic Neurotransmission: Functional Implications

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Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

There is substantial evidence from diverse sources to indicate an important interactive relationship between the cholinergic and dopaminergic systems in brain. It has been known for some time that dopaminergic agonists and antagonists exert a profound influence on the release, turnover, or concentration of striatal acetylcholine (ACh) (1–5). In general, the findings from such studies have suggested that the function of dopaminergic nigrostriatal fibers is to exert a tonic inhibitory influence on cholinergic interneurons. Likewise, cholinergic agents also seem to exert an effect on dopaminergic function. Systemic injections of muscarinic cholinergic agonists have been found to enhance the synthesis (6) and utilization (7–10) of striatal as well as mesolimbic dopamine (DA). Muscarinic antagonists, on the other hand, appear to reduce the rate of utilization of dopamine (6, 11–15).

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Authors and Affiliations

  1. Biological Psychiatry Branch, NIMH, Bethesda, Maryland, USA

    Agu Pert & Paul B. S. Clarke

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  1. Agu Pert
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  2. Paul B. S. Clarke
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Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Pert, A., Clarke, P.B.S. (1987). Nicotinic Modulation of Dopaminergic Neurotransmission: Functional Implications. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_12

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

  • eBook Packages: Springer Book Archive

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