Abstract
Over the past several years we have been investigating the characteristics of the immune responses to antigens from the outer membrane of gramnegative bacteria, and how these responses can be modulated by complexing the antigens with other components of the outer membrane. As a model for these studies, we have been using defined complexes produced from isolated, purified components of the outer membrane of Proteus mirabilis. In these complexes, the isolated components serve as immunogens and as modulators alike.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. Gmeiner and H. H. Martin, Phospholipid and lipopolysaccharide in Proteus mirabilis and its stable protoplast L-form. Difference in content and fatty acid composition, Eur. J. Biochem. 67:487 (1976).
N. K. Jerne and A. A. Nordin, Plaque formation in agar by single antibody-producing cells, Science 140:405 (1963).
H. Karch, J. Gmeiner and K. Nixdorff, Alteration of the immunoglobulin G subclass responses in mice to lipopolysaccharide: Effects of nonbacterial proteins and bacterial membrane phospholipids or outer membrane proteins of Proteus mirabilis, Infect. Immun. 40:157 (1983).
H. Karch and K. Nixdorff, Comparison of quantitative and qualitative antibody-producing cell responses to lipopolysaccharide in cell walls of the bacterial form and in membranes of the protoplast L-form of Proteus mirabilis, Infect. Immun. 30:349 (1980).
H. Karch and K. Nixdorff, Antibody-producing cell responses to an isolated outer membrane protein and to complexes of this antigen with lipopolysaccharide or with vesicles of phospholipids from Proteus mirabilis, Infect. Immun. 31:862 (1981).
H. Karch and K. Nixdorff, Modulation of the IgG subclass responses to lipopolysaccharide by bacterial membrane components: Differential adjuvant effects produced by primary and secondary stimulation, J. Immunol. 131:6 (1983).
H. -P. Kroll, J. Gmeiner and H. H. Martin, Membranes of the protoplast L-form of Proteus mirabilis, Arch. Microbiol. 127:223 (1980).
B. Lugtenberg, J. Meijers, R. Peters, P. van der Hoek and L. van Alphen, Electrophoretic resolution of the “major outer membrane protein” of Escherichia coli K12 into four bands, FEBS Lett. 58:254 (1975).
M. A. K. Markwell, S. M. Haar, L. L. Bieber and E. Tolbert, A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples, Anal. Biochem. 37:206 (1978).
H. H. Martin, Composition of the mucopolymer in cell walls of the unstable and stable L-form of Proteus mirabilis, J. Gen. Microbiol. 36:441 (1964).
H. H. Martin, D. Staboulis and W. Schilf, Penicillinbindeproteine als spezifische Wirkorte der beta-Lactam-Antibiotika und als Faktoren der Antibiotika-Resistenz, Immun. Infekt. 3:99 (1981).
R. I. Mishell and D. W. Dutton, Immunization of dissociated spleen cell cultures from normal mice, J. Exp. Med. 126:423 (1967).
K. Nixdorff, H. Fitzer, J. Gmeiner and H. H. Martin, Reconstitution of model membranes from phospholipid and outer membrane proteins of Proteus mirabilis. Role of proteins in the formation of hydrophilic pores and protection of membranes against detergents, Eur. J. Biochem. 81:63 (1977).
K. Nixdorff, H. H. Martin and N. Siegmund-Schultze, Changes in outer membrane composition after treatment of Proteus mirabilis with antibiotics, in: “The Influence of Antibiotics on the Host-Parasite Relationship II,” D. Adam, H. Hahn and W. Opferkuch, eds., Springer-Verlag, Berlin, Heidelberg, New York, in press (1985).
S. Raziuddin, R. F. Kibler and D. C. Morrison, Immunosuppression of experimental allergic encephalomyelitis. III. In vitro evidence for induction of suppressor T lymphocytes in draining lymph node cells of animals immunized with myelin basic protein complexed to lipopolysaccharides, J. Immunol. 128:2073 (1982).
E. Ruttkowski and K. Nixdorff, Qualitative and quantitative changes in the antibody-producing cell responses to lipopolysaccharide induced after incorporation of the antigen into bacterial membrane phospholipid vesicles, J. Immunol. 124:2548 (1980).
S. Schlecht and 0. Westphal, Uber die Herstellung von Antiseren gegen die somatischen (0-) Antigene von Salmonellen. II. Mitteilung: Untersuchungen uber Hamagglutinintiter, Zentralbl. Bakteriol. Parasitenkd. Infektionskr. Hyg. Abt. I. Prig. 205:487 (1967).
D. S. Stephens, Effect of antibiotics on surface proteins of Neisseria gonorrhoeae, in: “The Influence of Antibiotics on the Host-Parasite Relationship,” D. Adam, H. Hahn and W. Opferkuch, eds., Springer-Verlag, Berlin, Heidelberg, New York, in press (1985).
U. Taubeneck, Untersuchungen über die L-form von Proteus mirabilis Hauser. II. Entwicklung und Wesen der L-form, Z. Mikrobiol. 2:132 (1962).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Siegmund-Schultze, N., Schell, S., Nixdorff, K. (1987). Antibiotic Susceptibility of Bacteria as Related to Immunogenicity. In: Szentivanyi, A., Friedman, H., Gillissen, G. (eds) Antibiosis and Host Immunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1901-6_6
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1901-6_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9058-2
Online ISBN: 978-1-4613-1901-6
eBook Packages: Springer Book Archive