Skip to main content
SpringerLink
Log in

Muramyl Dipeptides, Host Immunity and Enhancement

  • Chapter
Antibiosis and Host Immunity

Abstract

Immunopotentiating agents can be used either to enhance immunologically specific responses, and/or to activate mechanisms of nonspecific host resistance. Actually, immunopotentiating products may turn out to be of major importance in cases of problem infections, mainly in the immunocompromised host, or for the treatment of immunodeficiences concomitant to certain chronic infectious diseases and occurring under various conditions such as malnutrition and old age.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Adam, Enhanced in vitro phagocytosis of different pathogens by human monocytes in the presence of antibiotics, in: “The Influence of Antibiotics on the Host-parasite Relationship,” H. U. Eickenberg, H. Hahn, and W. Opferkuch, eds., Springer-Verlag, Berlin (1982).

    Google Scholar 

  2. L. E. Adinolfi, P. F. Bonventre, M. Van der Pas, and D. A. Eppstein, Synergistic effect of glucantime and a liposome-encapsulated muramyl dipeptide analog in therapy of experimental visceral Leishmaniasis, Infect. Immun. 48:409 (1985).

    PubMed  CAS  Google Scholar 

  3. E. H. Beachey, B. I. Eisenstein, and I. Ofek, Sublethal concentrations of antibiotics and bacterial adhesion, in: “Adhesion and Microorganisms Pathogenicity,” K. Elliott, M. O’Connor, and J. Whelan, eds., Ciba Foundation Symp. 80, Pitman Medical Ltd., London (1980).

    Google Scholar 

  4. N. E. Byars, Two adjuvant-active muramyl dipeptide analogs induce differential production of lymphocyte-activating factor and a factor causing distress in guinea pigs, Infect. Immun. 44:344 (1984).

    PubMed  CAS  Google Scholar 

  5. L. Chedid, and F. Audibert, New approaches for control of infections using synthetic or semi-synthetic constructs containing MDP, Springer Semin. Immunopathol. (in press).

    Google Scholar 

  6. L. Chedid, M. Parant, F. Audibert, G. Riveau, F. Parant, E. Lederer,J. Choay, and P. Lefrancier, Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenieity, Infect. Immun. 35:417 (1982).

    PubMed  CAS  Google Scholar 

  7. L. Chedid, M. Parant, F. Parant, F. Audibert, P. Lefrancier, J. Choay, and M. Sela, Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)-poly(L-Lysine) carrier, Proc. Natl. Acad. Sci. USA 76:6557 (1979).

    Article  PubMed  CAS  Google Scholar 

  8. L. Chedid, M. Parant, F. Parant, P. Lefrancier, J. Choay, and E. Lederer, Enhancement of non-specific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs, Proc. Natl. Acad. Sci. USA 74:2089 (1977).

    Article  PubMed  CAS  Google Scholar 

  9. L. Chedid, M. Parant, and G. Riveau, Immunopharmacological activities of MDP, in: “Immunopharmacology and the Regulation of Leukocyte Function,” D. R. Webb, ed., Marcel Dekker, New York (1982).

    Google Scholar 

  10. L. Chedid, Muramyl peptides as possible endogenous immunopharmacological mediators, Microbiol. Immun. 27:723 (1983).

    CAS  Google Scholar 

  11. C. Damais, G. Riveau, M. Parant, J. Gerota, and L. Chedid, Production of lymphocyte-activating factor in the absence of endogenous pyrogen by rabbit or human leukocytes stimulated by a muramyl dipeptide derivative, Int. J. Immunopharmaco1. 4:451 (1982).

    Article  CAS  Google Scholar 

  12. F. M. Dietrich, B. Lukas, and K. H. Schmidt-Ruppin, MTP-PE (synthetic muramyl peptide): prophylactic and therapeutic effects in experimental viral infections, 13th Intern. Cong. Chemotherapy, Vienna, (1983).

    Google Scholar 

  13. F. M. Dietrich, W. Sackmann, G. H. Mitchell, and A. Voller, Modulation of resistance to infections by synthetic low-molecular-weight compounds endowed with immunostimulatory properties: experimental results and potential role in human medicine, in: “Chemotherapy and Immunology in the Control of Malaria, Filariasis, and Leishmaniasis,” N. Anand, and A. B. Sen, eds., Tata McGraw-Hill Publ., New-Dehli (1983).

    Google Scholar 

  14. F. M. Dietrich, W. Sackmann, O. Zak, and P. Dukor, Synthetic muramyl dipeptide immunostimulants: protective effects and increased efficacy of antibiotics in experimental bacterial and fungal infections in mice, in: “Current Chemotherapy and Infectious Disease, vol. 2,” J. D. Nelson, and G. Grassi, eds., Amer. Soc. Microbiol, (1981).

    Google Scholar 

  15. I. J. Fidler, and A. J. Schroit, Synergism between lymphokines and muramyl dipeptide encapsulated in liposomes: In situ activation of macrophages and therapy of spontaneous cancer metastases, J. Immunol. 133:515 (1984).

    PubMed  CAS  Google Scholar 

  16. I. J. Fidler, S. Sone, W. E. Fogler, D. Smith, D. G. Broun, L. Tarcsay, R. H. Gisler, and A. J. Schroit, Efficacy of liposomes containing a lipophilic muramyl dipeptide derivative for activating the tumoricidal properties of alveolar macrophages in vivo, J. Biol. Resp. Modif. 1:43 (1982).

    CAS  Google Scholar 

  17. E. B. Fraser-Smith, and T. R. Matthews, Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans, Infect. Immun. 34:676 (1981).

    PubMed  CAS  Google Scholar 

  18. E. B. Fraser-Smith, R. V. Waters, and T. R. Matthews, Correlation between in vivo anti-Pseudomonas and anti-Candida activities and clearance of carbon by the reticuloendothelial system for various muramyl dipeptide analogs, using normal and immunosuppressed mice, Infect. Immun. 35:105 (1982).

    PubMed  CAS  Google Scholar 

  19. H. Friedman, and G. Warren, Increased phagocytosis of Escherichia coli pretreated with subinhibitory concentration of cyclacillin or ampicillin, Proc. Soc. Exp. Biol. Med. 169:301 (1982).

    PubMed  CAS  Google Scholar 

  20. H. Friedman, and G. Warren, Muramyl dipeptide-induced enhancement of phagocytosis of antibiotic-pretreated Escherichia coli by macrophages, Proc. Soc. Exp. Biol. Med. 176:366 (1984).

    PubMed  CAS  Google Scholar 

  21. R. B. Galland, L. S. Trachtenberg, N. Rynerson, and H. C. Polk, Nonspecific enhancement of resistance to local bacterial infection in starved mice, Arch. Surgery 117:161 (1982).

    CAS  Google Scholar 

  22. M. J. Kluger, Historical aspects of fever and its role in disease, in: “Thermoregulatory Mechanisms and Their Therapeutic Implications,” B. Cox, P. Lomax, A. S. Milton, and E. Schonbaum, eds., S. Karger, Basel (1980).

    Google Scholar 

  23. S. Kotani, H. Takeda, M. Tsujimoto, T. Ogawa, Y. Mori, T. Koga, H. Iribe, A. Tanaka, S. Nagao, J. R. McGhee, S. M. Michalek, S. Kawata, T. Shiba, and S. Kusumoto, Lipophilic muramyl peptides and synthetic lipid A analogs as immunomodulators, in: “Progress in Immunology V,” Y. Yamamura, and T. Tada, eds., Academic Press, Japan (1983).

    Google Scholar 

  24. S. Kotani, Y. Watanabe, T. Shimono, K. Harada, T. Shiba, S. Kusumoto, K. Yokogawa, and M. Taniguchi, Correlation between the immuno-adjuvant activities and pyrogenicities of synthetic N-acetylmuramyl peptides or -aminoacids, Biken J. 19:9 (1976).

    PubMed  CAS  Google Scholar 

  25. C. Leclerc, E. Bourgeois, and L. Chedid, Demonstration of muramyl dipeptide (MDP)-induced T suppressor cells responsible for MDP immunosuppressive activity, Europ. J. Immunol. 12:249 (1982).

    Article  CAS  Google Scholar 

  26. C. Leclerc, and L. Chedid, Macrophage activation by synthetic muramyl peptides, in: “Lymphokines 7,” E. Pick, ed., Academic Press, New York (1982).

    Google Scholar 

  27. E. Lederer, Synthetic immunostimulants derived from the bacterial cell wall, J. Med. Chem. 23:819 (1980).

    Article  PubMed  CAS  Google Scholar 

  28. P. Lefrancier, and E. Lederer, Chemistry of synthetic immunomodulant muramyl peptides, Prog. Chem. Org. Nat. Prod. 40:1 (1981).

    Google Scholar 

  29. K. Matsumoto, H. Ogawa, T. Kusama, O. Nagase, N. Sawaki, M. Inage, S. Kusumoto, T. Shiba, and I. Azuma, Stimulation of nonspecific resistance to infection induced by 6–0-acylmuramyl dipeptide analogs in mice, Infect. Immun. 32:748 (1981).

    PubMed  CAS  Google Scholar 

  30. Y. Osada, M. Mitsuyama, K. Matsumoto, T. Une, T. Otani, H. Ogawa, and K. Nomoto, Stimulation of resistance of immunocompromised mice by a muramyl dipeptide analog, Infect. Immun. 37:1285 (1982).

    PubMed  CAS  Google Scholar 

  31. Y. Osada, M. Mitsuyama, T. Una, K. Matsumoto, T. Otani, M. Satoh, H. Ogawa, and K. Nomoto, Effect of L18-MDP(Ala), a synthetic deriva-tive of muramyl dipeptide, on nonspecific resistance of mice to microbial infections, Infect. Immun. 37:292 (1982).

    PubMed  CAS  Google Scholar 

  32. T. Otani, K. Katami, T. Une, Y. Osada, and H. Ogawa, Restoration by MDP-Lys (L18) of resistance to Pseudomonas pneumoniae in immunosuppressed guinea-pigs, Microbiol. Immunol. 28:1077 (1984).

    PubMed  CAS  Google Scholar 

  33. M. Parant, F. Audibert, L. Chedid, M. Level, P. Lefrancier, J. Choay,and E. Lederer, Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of a desmuramyl peptidolipid analog, Infect. Immun. 27:826 (1980).

    PubMed  CAS  Google Scholar 

  34. M. Parant, and L. Chedid, Stimulation of nonspecific resistance to infections by synthetic immunoregulatory agents, Infection 12:230 (1984).

    Article  PubMed  CAS  Google Scholar 

  35. M. Parant, N. K. Masihi, W. Lange, W. Brehmer, F. Parant, M. Jolivet, and L. Chedid, Enhancement of nonspecific resistance to bacterial and viral infections by MDP conjugated to tetanus toxoid or viral subunits, submitted for publication.

    Google Scholar 

  36. M. Parant, F. Parant, L. Chedid, A. Yapo, J-F. Petit, and E. Lederer, Fate of the synthetic immunoadjuvant, muramyl dipeptide ( C-labeled) in the mouse, Int. J. Immunopharmacol. 1:35 (1979).

    Article  PubMed  CAS  Google Scholar 

  37. M. Parant, Biological properties of a new synthetic adjuvant, muramyl dipeptide (MDP), Springer Semin. Immunopathol. 2:101 (1979).

    Article  CAS  Google Scholar 

  38. M. Parant, Bacterial immunoregulatory agents, in: “Regulation of the Immune Response,” P. L. Ogra, and D. M. Jacobs, eds., S. Karger AG, Basel (1983).

    Google Scholar 

  39. N. C. Phillips, M. L. Moras, L. Chedid, P. Lefrancier, and J. M. Bernard, Activation of alveolar macrophage tumoricidal activity and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative, Cancer Res. 45:128 (1985).

    PubMed  CAS  Google Scholar 

  40. H. C. Polk, R. B. Galland, and J. R. Ausobsky, Nonspecific enhancement of resistance to bacterial infection. Evidence of an effect supplemental to antibiotics, Ann. Surgery. 196:436 (1982).

    Article  CAS  Google Scholar 

  41. H. Pruul, B. L. Wetherall, and P. J. McDonald, Enhanced susceptibility of Escherichia coli to intracellular killing by human polymorpho-nuclear leukocytes after in vitro incubation with chloramphenicol, Antimicrob. Agents Chemother. 19:945 (1981).

    PubMed  CAS  Google Scholar 

  42. W. Sackmann, and F. M. Dietrich, Experimental murine candidiasis: non-specific resistance induced by synthetic compounds with immunostimulatory properties, in: “Current Chemotherapy and Immunotherapy,” P. Periti, and G. Grassi, eds., Amer. Soc. Micro-biol. (1981).

    Google Scholar 

  43. M. J. Staruch, and D. D. Wood, The adjuvanticity of Interleukin-1 in vivo, J. Immunol. 130:2191 (1983).

    PubMed  CAS  Google Scholar 

  44. K. Vosbeck, Effects of low concentrations of antibiotics on Escherichia coli adhesion, in: “The Influence of Antibiotics on the Host-Parasite Relationship,” H. U. Eickenberg, H. Hahn, and W. Opferkuch, eds., Springer-Verlag, Berlin (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Pasteur, Paris, France

    Monique Parant & Louis Chedid

Authors
  1. Monique Parant
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Louis Chedid
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Pharmacology and Therapeutics and Internal Medicine, University of South Florida, College of Medicine, 12901 N. 30th Street, Box 9, Tampa, Florida, USA

    Andor Szentivanyi M.D. (University Distinguished Professor) (University Distinguished Professor)

  2. Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, 12901 N. 30th Street, Box 10, Tampa, Florida, USA

    Herman Friedman Ph.D. (Professor and Chairman) (Professor and Chairman)

  3. Department of Medical Microbiology, Faculty of Medicine, Rhein.-Westfälische Technische Hochschule Aachen, 5100, Aachen, Federal Republic of Germany

    Günther Gillissen M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Parant, M., Chedid, L. (1987). Muramyl Dipeptides, Host Immunity and Enhancement. In: Szentivanyi, A., Friedman, H., Gillissen, G. (eds) Antibiosis and Host Immunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1901-6_33

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1901-6_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9058-2

  • Online ISBN: 978-1-4613-1901-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation