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Antibiosis and Host Immunity pp 265–276Cite as

Attempts to Explain Immunological Side Effects of Antibiotics on the Production of Cellular Mediators

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Abstract

A prerequisite for an optimal therapeutic effect of antimicrobial chemotherapy is not only an adequate antibiotic but also a functionally intact immune system (2,3,72). The latter requirement applies to bacteriostatic drugs as well as to bactericidal ones. A state of primary or secondary immunodeficiency may, therefore, impair the therapeutic effect of antibiotics (22,43,56). In this context, the question arose if antibiotics influence immune defense mechanisms by themselves, i.e., besides their proper antimicrobial activity, immune defense mechanisms (19). Since methods for evaluating the immune status are increasingly available, this problem has become an area of growing interest. Many antibiotics have been assayed in vitro and in vivo with regard to their influence on different immunological parameters (15,16,23–25,27,28,39). The aim of these experiments was to obtain predictive results whether an antibiotic will induce by itself, independent of its antimicrobial effect, an enhancement or depression of immune response.

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  1. Department of Medical Microbiology, Aachen, Germany

    Günther Gillissen (Medical Faculty)

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  1. Günther Gillissen
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Editors and Affiliations

  1. Departments of Pharmacology and Therapeutics and Internal Medicine, University of South Florida, College of Medicine, 12901 N. 30th Street, Box 9, Tampa, Florida, USA

    Andor Szentivanyi M.D. (University Distinguished Professor) (University Distinguished Professor)

  2. Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, 12901 N. 30th Street, Box 10, Tampa, Florida, USA

    Herman Friedman Ph.D. (Professor and Chairman) (Professor and Chairman)

  3. Department of Medical Microbiology, Faculty of Medicine, Rhein.-Westfälische Technische Hochschule Aachen, 5100, Aachen, Federal Republic of Germany

    Günther Gillissen M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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Gillissen, G. (1987). Attempts to Explain Immunological Side Effects of Antibiotics on the Production of Cellular Mediators. In: Szentivanyi, A., Friedman, H., Gillissen, G. (eds) Antibiosis and Host Immunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1901-6_30

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  • DOI: https://doi.org/10.1007/978-1-4613-1901-6_30

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