Abstract
Treatment with antibiotics may have a direct effect on both bacterial virulence as well as host defense systems. Indeed several antimicrobial agents are known to affect immunological responses significantly (10). Certain antibiotics can suppress lymphocyte function in vitro (1,6). The present investigation was undertaken to evaluate the effects of two antibiotic families, macrolides and new quinoline carboxylic acid derivatives on mitogen-stimulated human peripheral blood mononuclear leucocyte (MNL) responses. We demonstrated that erythromycin, spiramycin, ciprofloxacin, pefloxacin and ofloxacin suppressed significantly lymphocyte transformation. In a second part, we evaluated the effects of thiol compounds as antioxidant agents, essentially 2-Mercaptoethanol (2-ME) on protection of the depressed immune response induced by high antibiotic concentrations. Our results clearly showed that 2-ME can partially protect the lymphocyte proliferation depressed by these antibiotics.
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© 1987 Plenum Press, New York
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Pocidalo, JJ., Roche, Y., Levacher, M., Gougerot-Pocidalo, MA. (1987). Antibiotics and Suppression of Lymphocyte Response in Vitro: Protection by Thiol Compounds. In: Szentivanyi, A., Friedman, H., Gillissen, G. (eds) Antibiosis and Host Immunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1901-6_28
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DOI: https://doi.org/10.1007/978-1-4613-1901-6_28
Publisher Name: Springer, Boston, MA
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