Antibacterial Activity of Monocytes and Macrophages against StaphylococcusAureus and KlebsiellaPneumoniae in Combination with Latamoxef

  • H.-M. Just
  • M. T. Ramos Carneiro Leao
  • F. D. Daschner
  • R. Andreesen

Abstract

There are mainly two functional morphologically different phagocytic cell populations in human peripheral blood, responsible for the defense mechanism against infections, polymorphonuclear leukocytes and monocytes, both deriving from precursor cells in the bone marrow. To transform monocytes into macrophages, monocytes have been cultured on artificial membranes (7), showing properties of typical macrophages during a period of eight to 12 days (4,20). Our initial objective was to determine the effect of different stages of maturity of Teflon membrane cultivated mononuclear cells, on the killing-rate of Staphylococcus aureus and Klebsiella pneumoniae. Furthermore, the influence of normal and heat-inactivated human pooled serum, the effect of latamoxef, and the variability between individuals in the function of mononuclear phagocytes were evaluated.

Keywords

Smoke Gelatin Ampicillin Tetracycline Candida 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H.-M. Just
    • 1
  • M. T. Ramos Carneiro Leao
  • F. D. Daschner
  • R. Andreesen
    • 2
  1. 1.Department of Hospital EpidemiologyUniversity Hospital of FreiburgGermany
  2. 2.Department of Haemathology and OncologyUniversity Hospital of FreiburgGermany

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