Abstract
The pathogenesis of bacteria for man is dependent upon a number of factors, some of which are engendered in the bacterial invader and others are based on the specific and non-specific defenses of the host. It is the outcome of the close interaction of these different factors which determines whether or not a life-threatening infection occurs. It is in exceptional circumstances when the specific strain of bacterial invader carries extraordinary virulence characteristics or when the host is immunocompromised that the balance becomes grossly disturbed in favor of the pathogen. The use of antibiotics in therapy becomes extremely important in this situation and this subject is addressed in several of the contributions to this volume. Some examples of the ways in which certain bacterial pathogens can avoid or overcome the serum-mediated or phagocytic cell-mediated defenses ot the host are summarized in Tables 1 and 2.
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© 1987 Plenum Press, New York
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Gemmell, C.G. (1987). Antibiotic-Induced Changes in the Pathogenicity of Bacteria and Their Influence on the Interaction of Bacteria with Phagocytic Cells in Vitro and in Vivo. In: Szentivanyi, A., Friedman, H., Gillissen, G. (eds) Antibiosis and Host Immunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1901-6_19
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DOI: https://doi.org/10.1007/978-1-4613-1901-6_19
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