The Effect of Some Antibiotics on Interferon Production

  • M. Ghione
  • A. Pugliese
  • A. Valpreda
  • C. Salomone
  • P. Martinetto
  • P. A. Tovo


The commonly used antibacterial drugs are selected on the basis of their effect on the structure and function of prokaryotic cells but they are not devoid of action on eukaryotic cells. This can be due to the fact that eukaryotic cells include prokaryotic-like structures (such as mitochondria) and have several functions and metabolic mechanisms very similar to the prokaryotic ones.


Peripheral Blood Lymphocyte Newcastle Disease Virus Newcastle Disease Antibacterial Drug Interferon Production 
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  1. 1.
    L. Athlin, L. Domellof and B. Norberg, Adherence and phagocytosis of yeast cells by blood monocytes, effects in vitro of a therapeutic doxyciclin concentration, Acta Path. Microbiol. Immunol. Scand. Sect C 92:227 (1984).Google Scholar
  2. 2.
    D. Cortese, A. Pugliese and P. A. Tovo, Effetto di Rifampicina sulla produzione di interferon, Atti XIX Cong. Naz. Soc. Ital. Microbiol., Catania, 5–8 giugno (1980).Google Scholar
  3. 3.
    J. G. R. Elferink and M. Deierkauf, Inhibition of polymorphonuclear leukocyte functions by chlortetracycline, Biochem. Pharmacol. 33:3667 (1984).PubMedCrossRefGoogle Scholar
  4. 4.
    M. Ghione, Influenza di farmaci antibatterici su processi inflammatori e immunitari, Giorn. Ital. Chemiot. 26:97 (1979).Google Scholar
  5. 5.
    M. Ghione, Toxicology of antimicrobial agents: effect of antimicrobial agents on the immune system, in: “Clinical Chemo-therapy,” H. P. Kuemmerle, ed., Thieme Stratton 1:373 (1983).Google Scholar
  6. 6.
    M. Ghione, Antibiotici e difese organiche, Medico e Bambino 6:348 (1984).Google Scholar
  7. 7.
    G. Gillissen, Possible mechanisms of immunological side-effects of antibiotics, Zbl. Bakt. Suppl. 13:91 (1985).Google Scholar
  8. 8.
    Martindale, The extra pharmacopeia, 28 ed., J. E. F. Reynolds, ed., The Pharmaceutical Press, London (1982).Google Scholar
  9. 9.
    T. C. Merigan and H. Friedman, eds., “Interferon,” UCLA Symposia Mol. Cell. Biol. (1982).Google Scholar
  10. 10.
    H. K. Oie, C. E. Buckler, C. P. Uhlendorf, D. A. Hill and S. Baron, Improved assay for a variety of interferon, Proc. Soc. Exp. Biol. Med. 140:1178 (1972).PubMedGoogle Scholar
  11. 11.
    A. Pugliese and P. A. Tovo, Effect of Distamycin A on the production of interferon induced in vitro by the NDV virus, Acta Virol. 25:62 (1981).PubMedGoogle Scholar
  12. 12.
    H. Rollag, Jr. and M. Degrè, Effect of antibiotics on interferon production in mice, Acta Path. Microb. Scand. Sect. B 84:369 (1976).Google Scholar
  13. 13.
    P. A. Tovo, M. Vitale, F. Tridico and A. Pugliese, Effetto di trattamenti a lungo termine con Rifampicina Cloramfenicolo e Cortisone sulla produzione di interferon virus-indotto, Giorn. Batt. Virol. Immun. 75:1 (1982).Google Scholar
  14. 14.
    S. Ustacelebi and J. F. Williams, Depression of interferon production in chick embryo cells by Rifampicin, J. Gen. Virol. 15:139 (1972).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Ghione
    • 1
  • A. Pugliese
    • 2
  • A. Valpreda
    • 2
  • C. Salomone
    • 3
  • P. Martinetto
    • 4
  • P. A. Tovo
    • 3
  1. 1.Instituto di Microbiologia MedicaUniversità di MilanoItaly
  2. 2.Instituto di Malattie InfettiveUniversità di TorinoItaly
  3. 3.Clinica PediatricaUniversità di TorinoItaly
  4. 4.Instituto di MicrobiologiaUniversità di TorinoItaly

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