The emergence and evolution of the immune and idiotypic repertoires of the immune system are closely intertwined, given that idiotypes are after all the antigenic markers of the antibody molecule’s variable region. Those factors which can affect the expression of these two repertoires will differ according to the maturity of the immune system. At this point we would like to distinguish between those forces affecting the primary or early repertoire versus those influencing the expression of the later secondary repertoire.
KeywordsGermline Gene Light Chain Variable Region Germline Versus Germline Versus Gene Immunogenic Challenge
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