Antibodies pp 91-105 | Cite as

Network and Regulation of the Idiotypic Repertoire

  • Carol Victor-Kobrin
  • Zahava Barak
  • F. A. Bonilla
  • Constantin Bona

Abstract

The emergence and evolution of the immune and idiotypic repertoires of the immune system are closely intertwined, given that idiotypes are after all the antigenic markers of the antibody molecule’s variable region. Those factors which can affect the expression of these two repertoires will differ according to the maturity of the immune system. At this point we would like to distinguish between those forces affecting the primary or early repertoire versus those influencing the expression of the later secondary repertoire.

Keywords

Influenza Myeloma Lysozyme Inulin Phosphocholine 

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References

  1. 1.
    C. Auffrey, J. L. Sikorav, R. Olio, and F. Rougeon, Correlation between D region structure and antigen-binding specificity: evidence from the comparison of closely related immunoglobulin VH sequences, Ann. Immunol. (Inst. Pasteur) 132d: 77 (1981).Google Scholar
  2. 2.
    C. A. Bona, E. Heber-Katz, and W. G. Paul, Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti(anti-idiotype) antibodies and to activation of silent clones, J. Exp. Med. 153: 951 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    P. H. Brodeur and R. Riblet, The immunoglobulin heavy chain variable region (Igh-V) locus in mouse. I. One hundred Igh-V genes comprise seven families of homologous genes, Eur. Immunol. 14: 922 (1984).CrossRefGoogle Scholar
  4. 4.
    M. P. Cancro, M. A. Thompson, S. Raychandhuri, and D. Hibbert, Ontogeny of the HA-responsive B cell repertoire. Interaction of heritable and inducible mechanisms in the establishment of phenotype in idiotype in biology and medicine, H. Kohler, J. Urbain, and P. A. Cazenave, eds., Academic Press, New York (1984).Google Scholar
  5. 5.
    R. Dildrop, V. Krawinkel, E. Winter, and K. Rajewsky, VH gene expression in murine lipopolysaccharide blasts distributes over the nine known VH gene groups and may be random, Eur. J. Immunol. 15: 1154 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    B. Goldberg, W. E. Paul, and C. A. Bona, Idiotype anti-idiotype regulation. IV. Expression of common regulatory idiotopes on fruetosan-binding and non-fructosan binding monoclonal immunoglobulin, J. Exp. Med. 158: 515 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    A. B. Hartman and S. Rudikoff, JH genes encoding the immune response to β(1,6)-galactan: somatic mutation in IgM molecules, EMBO J. 3: 3023 (1984).PubMedGoogle Scholar
  8. 8.
    J. Hiernaux, C. Bona, and P. J. Baker, Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone, J. Exp. Med. 153: 1004 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    E. A. Kabat, T. T. Wu, H. Bilofsky, M. Reid-Miller, and H. Perry, Sequences of proteins of immunological interest, U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland (1983).Google Scholar
  10. 10.
    P. Legrain, D. Noegtle, G. Buttin, and P. A. Cazenave, Idiotype anti-idiotype interactions and the control of the anti-2,6 polyfructosan response in the mouse: specificity and idiotypy of anti-ABPC48 antiidiotype monoclonal antibodies, Eur. Immunol. 11: 678 (1981).CrossRefGoogle Scholar
  11. 11.
    P. Legrain, J. Rocca-Serra, A. Moulin, M. Fougereau, and G. Buttin, A single gene associated with a variety of D- and J-segments encodes for a large family of ABPC48 related antibodies induced by anti-idio-typic immunization, Mol. Immunol. 22: 437 (1985).PubMedCrossRefGoogle Scholar
  12. 12.
    M. Pawlita, E. Mushinsky, R. J. Feldman, and M. Potter, A monoclonal antibody that defines an idiotype with two subsites in galactan-binding myeloma patients, J. Exp. Med. 154: 1946 (1981).PubMedCrossRefGoogle Scholar
  13. 13.
    L. J. Rubinstein, C. B. Victor-Kobrin, and C. A. Bona, The function of idiotypes and anti-idiotypes on the development of the immune repertoire, Devel. Comp. Immunol. Suppl. 3: 109 (1984).Google Scholar
  14. 14.
    D. S. Strayer, W.M.F. Lee, D. A. Rowley, and H. Kohler, Anti-receptor antibody. II. Induction of long-term unresponsiveness in neonatal mice, J. Immunol. 114: 728 (1985).Google Scholar
  15. 15.
    C. Victor-Kobrin, F. A. Bonilla, B. Bellon, and C. A. Bona, Immuno-chemical and molecular characterization of regulatory idiotopes expressed by monoclonal antibodies exhibiting or lacking β2,6 fructosan binding activity, J. Exp. Med. 162: 697 (1985).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Carol Victor-Kobrin
    • 1
  • Zahava Barak
    • 1
  • F. A. Bonilla
    • 1
  • Constantin Bona
    • 1
  1. 1.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA

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