Abstract
The ubiquity of a brain peptide involved in regulating pituitary gonadotropin (Gn) secretion in vertebrates has been confirmed by a variety of direct and indirect studies.57 This gonadotropin-releasing hormone (GnRH) [also known as luteinizing hormone-releasing hormone (LHRH)] has been extensively characterized biochemically and physiologically in mammals, but data for nonmammalian species are still very limited. Indeed, our use of the term GnRH, unless specified otherwise, will refer to the mammalian decapeptide:
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References
Alderete, M.R., Tokarz, R.R. and Crews, D. (1980). Luteinizing hormone-releasing hormone (LHRH) and thyrotropin releasing hormone (TRH) induction of female sexual receptivity in the lizard, Anolis carolinensis. Neuroendocrinology 30, 200–205.
Alpert, L.C., Brawer, J.R., Jackson, I.M.D., and Reichlin, S. (1976). Localization of LH-RH in neurons in frog brain (Rana pipiens and Rana catesbeiana). Endocrinology 98, 910–921.
Andreoletti, G.E., Mazzi, V., Vellano, C. and Sacerdote, M. (1980). Effects of LHRH on spermiation and serum testosterone levels in the winter newt, Triturus cristatus carnifex (Laur.). Monitore zool. ital. (N.S.) 14, 255–262.
Arslan, M., Saulat, T., Saeed, S.A. and Qazi, M.H. (1985). Regulation of gonadal function in a lizard. IXth Intern. Congr. Comp. Endocrinol., Hong Kong. P58 (Abstr).
Ball, J.N. (1981). Hypothalamic control of the pars distalis in fishes, amphibians, and reptiles. Gen. Comp. Endocrinol. 44, 135–170.
Branton, W. D., Jan, L. Y., Jan, Y. N. (1982). Non-mammalian luteinizing hormone-releasing factor (LRF) in tadpole and frog brain. 12th Ann. Meeting, Soc. Neurosc, Minn. 1082, p. 14 (Abstr).
Bourne, G. A. and Baldwin, D. M. (1980). Extracellular CA++_independent and dependent components of the biphasic release of LH in response to luteinizing hormone-releasing hormone in vitro. Endocrinology 107, 780–788.
Callard, I.P., and Lance, V. (1977). The control of reptilian follicular cycles. In “Reproduction and Evolution” (Calaby, J.H. and Tyndale-Biscoe, C.H. ed.), pp. 199–210. Australian Acad. Sci., Canberra City.
Callard, I.P. and Scanes, C.G. (1975). Synthesis of radioimmunoassayable LH by suspended pituitary cells derived from the turtle, Chrysemys picta. Proc. 57th Annu. Meet. Endocrine Soc., New York. Abstr. 307.
Ciarcia, G., Angelini, F., Botte, V. (1983). Effects of a chronic treatment with the luteinizing hormone-releasing hormone agonist buserelin, on the gonads of the lizard Podarcis s. sicular Raf. Atti Accad. Nazion. dei Lincei, Rend Cl. Sci. fis., mat. Series VIII, 74, 425–429.
Crews, D. (1979). The neuroendocrinology of reproduction in reptiles. Biol. Reprod. 20, 51–73.
Crim, J.W. (1985). Immunocytochemistry of luteinizing hormonereleasing hormone and sexual maturation of the frog brain: comparisons of juvenile and adult bullfrogs (Rana catesbeiana). Gen. Comp. Endocrinol. 59, 424–433.
Crim, J.W. and Vigna, S.R. (1983). Brain, gut and skin peptide hormones in lower vertebrates. Amer. Zool. 23, 621–638.
Daniels, E. and Licht, P. (1980). Effects of gonadotropinreleasing hormone on the levels of plasma gonadotropins in the bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 42, 455–463.
Deery, D.J. (1974). Determination by radioimmunoassay of the luteinizing hormone-releasing hormone (LH-RH) content of the hypothalamus of the rat and some lower vertebrates. Gen. Comp. Endocrinol. 24, 280–285.
Demski, L.S. (1984). The evolution of neuroanatomical substrates of reproductive behavior: sex steroid and LHRH-specific pathways including the terminal nerve. Amer. Zool. 24, 809–830.
Dierickx, K. (1974). Identification of adenohypophysiotropic neurohormone producing cells in Rana temporaria. In “Neurosecretion --The final neuroendocrine pathway.” (Knowles, F. and Vollrath, L., eds.) pp. 170–181. Springer, Berlin.
Doerr-Schott, J. and Dubois M.P. (1978). Immunohistochemical localization of different peptidergic substances in the brain of amphibians and reptiles. In “Comparative Endocrinology” (Gaillard, P.J. and Boer, H.H., eds.), pp. 367–370. Elsevier, Amsterdam.
Easley, K.A., Culley, D.D., Jr., Horseman, N.D. and Penkala, J.E. (1978). Environmental influences on hormonally induced spermiation of the bullfrog, Rana catesbeiana. J. Exp. Zool. 207, 407–416.
Eiden, L.E., Loumaye, E., Sherwood, N., Eskay, R.L. (1982). Two chemically and immunologically distinct forms of luteinizing hormone-releasing hormone are differentially expressed in frog neural tissues. Peptides 3, 323–327.
Hall, T.R., Chadwick, A., Scanes, C.G. and Callard, I.P. (1978). Effects of hypothalamic extract and steroids on secretion of prolactin, growth hormone and luteinizing hormone from pituitaries of Chrysemys picta cultured in vitro. J. Endocrinol. 76, 169–170.
Hubbard, G.M. and Licht, P. (1985). In vitro study of the direct ovarian effects of gonadotropin releasing hormone (GnRH) in the frogs, Rana pipiens and Rana catesbeiana. Gen. Comp. Endocrinol. 60, 154–161.
Jan, L.Y. and Jan, Y.N. (1981). Role of an LHRH-like peptide as a neurotransmitter in sympathetic ganglia of the frog. Fed. Proc. 40, 2560–2564.
Jokura, Y. and Urano, A. (1985). An immunohistochemical study of seasonal changes in luteinizing hormone-releasing hormone and vasotocin in the forebrain and the neurohypophysis of the toad, Bufo japonicus. Gen. Comp. Endocrinol. 59, 238–245.
Jorgensen, C. B. (1968). Central nervous control of adenohypophysial functions. In “Perspectives in Endocrinology” (Barrington, E.J.W. and Jorgensen, C.B., eds.), pp. 469–541. Academic Press, London.
Kelley, D.B. (1982). Female sex behaviors in the South African clawed frog, Xenopus laevis; Gonadotropin-releasing, gonadotropic, and steroid hormones. Horm. Behav. 16, 158–174.
King, J.A. and Millar, R.P. (1979). Hypothalamic luteinizing hormone-releasing hormone content in relation to the seasonal reproductive cycle of Xenopus laevis. Gen. Comp. Endocrinol. 39, 309–312.
King, J.A. and Millar, R.P. (1980). Comparative aspects of vertebrate luteinizing hormone-releasing hormone structure and function in vertebrate phylogeny. Endocrinology 106, 707–717.
King, J.A. and Millar, R.P. (1984). Isolation and structural characterization of chicken hypothalamic luteinizing releasing hormone. J. Exp. Zool. 232, 419–423.
Lance, V.A., Vilet, K. and Bolaffi, J.L. (1985). Effect of mammalian luteinizing hormone-releasing hormone on plasma testosterone in male alligators, with observations on the nature of alligator hypothalamic gonadotropin releasing hormone. Gen. Comp. Endocrinol. 60, 138–143.
Licht, P. (1974). Induction of sperm release in frogs by mammalian gonadotropin-releasing hormone. Gen. Comp. Endocrinol. 23, 352–354.
Licht, P. (1979). Reproductive endocrinology of reptiles and amphibians. Ann. Rev. Physiol. 41, 337–351.
Licht, P. (1980). Evolutionary and functional aspects of pituitary gonadotropins in the green turtle, Chelonia mydas. Amer. Zool.20, 565–574.
Licht, P., Khorrami-Yaghoobi, P. and Porter, D.A. (1985). Effects of gonadectomy and steroid treatment on plasma gonadotropins and the response of superfused pituitaries to gonadotropin releasing hormone (GnRH) in the turtle Sternotherus odoratus. Gen. Comp. Endocrinol. 60, 441–449.
Licht, P., McCreery, B.R., Barnes, R. and Pang, R. (1983). Seasonal and stress related changes in plasma gonadotropins, sex steroids and corticosterone in the bullfrog, Rana catesbeiana. Gen. Comp.. Endocrinol. 50, 124–145.
Licht, P., McCreery, B.R. and Barnes, R. (1983). Relation between acute pituitary responsiveness to gonadotropin releasing hormone (GnRH) and the ovarian cycle in the bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 51, 148–153.
Licht, P., Millar, R., King, J.A., McCreery, B.R., Mondonca, M.T..,Bona-Gallo, A. and Lofts, B. (1984). Effects of chicken and mammalian gonadotropin-releasing hormones (GnRH) on in vivo pituitary gonadotropin release in amphibians and reptiles. Gen. Comp. Endocrinol. 54, 89–96.
Licht, P., Owen, D., Cliffton, K. and Penaflores, C. (1982). Changes in LH and progesterone associated with the nesting cycle of the olive ridley sea turtle, Lepidochelys olivacea. Gen. Comp. Endocrinol., 48, 247–253.
Licht, P. and Porter, D.A. (1985). In vivo and in vitro responses to gonadotropin releasing hormone in the turtle, Chrysemys picta, in relation to sex and reproductive stage. Gen. Comp. Endocrinol. 60, 75–85.
Licht, P. and Porter, D.A. (1985). LH secretion in response to gonadotropin releasing hormone (GnRH) by superfused pituitaries from two species of turtles. Gen. Comp. Endocrinol. 59, 442–448.
Malacarne, G. and Giacomoa, C. (1978). Lesions to the CNS and ovariectomy in Triturus cristatus carnifex Laur. Effects on sexual behavior. Atti. Accad. Sci. Torino Cl. Sci. Mat. Fis. Natur. 112, 49–61.
Mazzi, V. (1970). The hypothalamus as a thermodependent neuroendocrine center in urodeles. In “The hypothalamus” (Martini, L., Motta, M. and Frashchini, F. eds.) pp. 663–676. Academic Press, New York.
Mazzi, V. (1978). Effects on spermatogenesis of permanent lesions of the rostral preoptic area in the crested newt (Triturus cristatus carnifex, Laur.). Gen. Comp. Endocrinol. 34, 247–250.
Mazzi, V., Vellano, C. and Bona, A. (1974). Oocyte recruitment in the ovaries of aestivating pituitary-autografted hypophysectomized female newts treated with synthetic LH-RH. Atti. Accad. Sci. Torino (I Cl., Sci. mat. fis. nat.) 108, 405–411.
Mazzi, V., Vellano, C., Colluci, D., and Merlo, A. (1974). Gonadotropin stimulation by chronic administration of synthetic luteinizing hormone releasing hormone in hypophysectomized pituitary grafted male newts. Gen. Comp. Endocrinol. 24, 1–9.
McCreery, B.R. (1984). Pituitary gonadotropin release by graded electrical stimulation of the preoptic area in the male bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 55, 367–372.
McCreery, B.R. and Licht, P. (1983). Induced ovulation and changes in pituitary responsiveness to continuous infusion of gonadotropinreleasing hormone (GnRH) during the ovarian cycle in the bullfrog, Rana catesbeiana. Biol. Reprod. 29, 863–87.
McCreery, B.R. and Licht, P. (1983). Pituitary and gonadal responses to continuous infusion of gonadotropin releasing hormone (GnRH) in the male bullfrog, Rana catesbeiana. Biol. Reprod. 29, 129–136.
McCreery, B.R. and Licht, P. (1984). The role of androgen in the development of sexual differences in pituitary responsiveness to gonadotropin releasing hormone (GnRH) agonist in the bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 54, 350–359.
McCreery, B.R. and Licht, P. (1984). Effects of gonadectomy and sex steroids on pituitary gonadotropin release and response to gonadotropin releasing hormone (GnRH) agonist in the bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 54, 283–295.
McCreery, B.R., Licht, P., Barnes, R., Rivier, J. and Vale, W. (1982). Actions of agonistic and antagonistic analogs of gonadotropin releasing hormone (Gn-RH) in the bullfrog, Rana catesbeiana. Gen. Comp. Endocrinol. 46, 511–520.
Millar, R.P. and King, J.A. (1984). Structure-activity relations of LHRH in birds. J. Exp. Zool. 232, 425–430.
Moore, F.L., Miller, L.J., Spielvogel, S.P., Kubiak, T. and Folkers, K. (1982). Luteinizing hormone-releasing hormone involvement in the reproductive behavior of a male amphibian. Neuroendocrinology 35, 212–216.
Moore, F.L. and Zoeller, R.T. (1985). Stress-induced inhibition of reproduction. Evidence of suppressed secretion of LHRH in an amphibian. Gen. Comp. Endocrinol. 60, 252–258.
Nozaki, M., Tsukahara, T. and Kobayashi, H. (1984). Neuronal systems producing LHRH in vertebrates. In “Endocrine correlates of reproduction” (Ochiai, K., Arai, Y., Shioda, T. and Takahashi, M., eds.), pp. 3–27. Japan Sci. Soc. Press, Tokyo.
Pearson, A.K. and Licht, P. (1982). Morphology and immunocytochemistry of the turtle pituitary gland with special reference to the pars tuberalis. Cell Tissue Res. 22, 81–100.
Peter, R.E. (1983). Evolution of neurohormonal regulation of reproduction in lower vertebrates. Amer. Zool. 23, 685–695.
Phillips, J.A., Alexander, N., Karesh, W.B., Millar, R. and Lasley, B.L. (1985). Stimulating male sexual behavior with repetitive pulses of GnRH in female green iguanas, Iguana. iguana. J. Exp. Zool. 234.
Pierantoni, R., Fasano, S., DiMatteo, L., Minucci, S., Varriale, B., Chieffi, G. (1984). Stimulatory effect of a GnRH agonist (buserelin) in in vitro and in vivo testosterone production by the frog (Rana esculenta) testis. Mol. Cell. Endocr. 38, 215–219.
Pierantoni, R., Iela, L. D’Istria, M., Fasano, S., Rastogi, R.K., Delrio, G. (1984). Seasonal testosterone profile and testicular responsiveness to pituitary factors and gonadotrophin releasing hormone during two different phases of the sexual cycle of the frog (Rana esculenta). J. Endocr. 102, 387–392.
Porter, D.A. (1985). The effects of cycloheximide on in vitro response of Rana pipiens pituitaries to continuously superfused gonadotropin-releasing hormone (GnRH). Biol. Reprod. 33, 393–400.
Porter, D.A. and Licht, P. (1985). Pituitary responsiveness to superfused gonadotropin releasing hormone in two species of ranid frogs. Gen. Comp. Endocrinol. 59, 308–315.
Powell, R.C., King, J.A. and Millar, R.P. (1985). [Trp7, Leu8] LH-RH in reptilian brain. Peptides 6, 223–227.
Rivier, J., Rivier, C., Branton, D., Millar, R., Spiess, J. and Vale, W. (1981). HPLC purification of ovine CRF, rat extrahypothalmic brain somatostatin and frog brain GnRH. In “Peptides: Synthesis-structure-function” (Rich, D.H. and Gross, E., eds.), pp. 771–776. Proc. Seventh Amer. Peptide Symposium, Pierce Chem. Co., Rock
Segal, S.J. and Adejuwon, C.A. (1979). Direct effect of LHRH on testicular steroidogenesis in Rana pipiens. Biol. Bull. 157, 393.
Sherwood, N.M., Zoeller, R.T. and Moore, F.L. (1986). Multiple forms of gonadotropin-releasing hormone in amphibian brains. Gen. Comp. Endocrinol. 61, 313–322.
Smith-Gill, S.J. and Berven, K.A. (1980). In vitro fertilization and assessment of male reproductive potential using mammalian gonadotropin-releasing hormone to induce spermiation in Rana sylvatica. Copeia 1980, 723–728.
Thornton, V.F. and Geschwind, I.I. (1974). Hypothalamic control of gonadotropin release in amphibians: Evidence from studies of gonadotropin release in vitro and in vivo. Gen. Comp. Endocrinol. 23, 294–301.
Van Deusen, E. (1973). Experimental studies on a mutant gene (e) preventing the differentiation of eye and normal hypothalamus primordia in the axolotl. Dev. Biol. 34, 135–158.
Vellano, C., Bona, A., Mazzi, V. and Colucci, D. (1974). The effect of synthetic luteinizing hormone releasing hormone on ovulation in the crested newt. Gen. Comp. Endocrinol. 24, 338–340.
Wheeler, J.M. and Crews, D. (1978). The role of the anterior hypothalamus preoptic area in the regulation of male reproductive behavior in the lizard, Anolis carolinensis: Lesion studies. Horm. Behav. 11, 42–60.
Zoeller, R. T. (1982). Changes in LHRH content of infundibulum, preoptic and septal areas following castration of male newts. Amer. Zool. 22, 954 (Abstr. 579).
Zoeller, R.T. and Moore, F. L. (1985). Seasonal changes in LHRH concentrations in microdissected brain regions of male rough-skinned newts (Taricha granulosa). Gen. Comp. Endocrinol. 58, 222–230.
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Licht, P., Porter, D.A. (1987). Role of Gonadotropin-Releasing Hormone in Regulation of Gonadotropin Secretion from Amphibian and Reptilian Pituitaries. In: Norris, D.O., Jones, R.E. (eds) Hormones and Reproduction in Fishes, Amphibians, and Reptiles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1869-9_3
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